益生菌干预艰难梭菌感染的研究进展

Progress in probiotics for treating Clostridioides difficile infection

艰难梭菌感染(Clostridioides difficile infection,CDI)是以发热、腹痛、腹泻为主要临床表现的一种感染性疾病,目前治疗措施主要包括抗生素疗法、粪菌移植疗法等,但复发性、难治性CDI仍不断增加,寻求一种更有效的替代疗法迫在眉睫,目前已有大量益生菌防治CDI的研究,但其研究尚处于初期阶段,本文通过对益生菌干预CDI的种类、机制及技术手段方面的研究加以综述,以期推动益生菌防治CDI的研究进程。

Clostridioides difficile infection(CDI)is an infectious disease with fever,abdominal pain and diarrhea as the main clinical manifestations.At present,CDI is mainly treated with antibiotics and faecal microbiota transplantation.As recurrent and refractory CDI continues to increase,it is important to seek a more effective alternative therapy.However,many of the studies on the prevention and control of CDI by probiotics are still in the early stage.This paper summarized the research on the types,mechanisms and technical means of probiotics in the treatment of CDI.