外泌体及lncRNA与川崎病关系的研究进展

Research progress on the relationship between exosomal and long non-coding RNA and Kawasaki disease

川崎病(Kawasaki disease,KD)是一种以全身急性血管炎性病变为主要特征的自身免疫性疾病,是儿童后天性心脏病最常见的病因,但目前发病机制尚未完全阐明,尚无特异性的生物标志物用于其诊断及预测治疗效果。外泌体及长链非编码RNA(long non-coding RNA,lncRNA)的异常表达在包括KD在内的多种疾病的进展中发挥着关键作用,能够反映疾病的进展及预后情况,有望成为特异性生物标志物及治疗靶点。本文综述了外泌体在KD中的作用及近年来发现的与KD相关的lncRNA,推测lncRNA可能参与了调节KD发生过程中的EndMT。

Kawasaki disease(KD) is an autoimmune disease characterized by systemic acute vasculitis, and is the most common cause of acquired heart disease in children. However, the pathogenesis has not been fully clarified yet, and there is no specific biomarker for its diagnosis and treatment prediction. Abnormal expression of exosomes and long non-coding RNA plays a key role in the progression of various diseases including KD,which can reflect the progression and prognosis of diseases, and is expected to become specific biomarkers and therapeutic targets. This paper reviews the role of exosomes in KD and the lncRNA related to KD discovered in recent years, and speculated that lncRNA may be involved in the regulation of EndMT in KD.