脂肪酸代谢在急性髓系白血病中的研究进展

Research progress of fatty acid metabolism in acute myeloid leukemia

脂肪酸代谢增强是肿瘤细胞常见的代谢改变之一。快速增殖的肿瘤细胞通过增加脂肪酸合成及分解代谢获取能量以及合成生物大分子支持自身生长、侵袭、转移、复发和耐药。在急性髓系白血病(acute myeloid leukemia,AML)中,AML细胞通过异常高表达脂肪酸代谢酶,且与骨髓脂肪细胞的相互作用,增加脂肪酸利用。上调的脂肪酸代谢促进AML细胞的生存增殖、药物耐药以及免疫逃逸。因此,在AML中靶向脂肪酸代谢有望成为治疗的新思路。本文就脂肪酸代谢在AML中的研究进展作一综述。

Enhanced fatty acid metabolism is one of the common metabolic changes in tumor cells. Through increasing fatty acid synthesis and catabolism, rapidly proliferating tumor cells obtain energy, and synthesize biological macromolecules to support their own growth, invasion, metastasis, recurrence, and drug resistance.In acute myeloid leukemia(AML), AML cells increase fatty acid utilization through abnormally high expression of fatty acid metabolizing enzymes and interaction with bone marrow adipocytes. Up-regulated fatty acid metabolism promotes AML cells survival, drug resistance, and immune escape. Therefore, targeting fatty acid metabolism in AML is expected to become a new idea for treatment. This paper reviews the research progress of fatty acid metabolism in AML.