他克莫司治疗干眼的作用机制和临床应用

Mechanism and clinical application of tacrolimus in treatment of dry eye disease

免疫相关性炎性反应在干眼的发病机制中起重要作用。他克莫司(FK506)通过抑制T淋巴细胞内的钙调神经磷酸酶或丝裂原活化蛋白激酶信号通路,抑制眼表细胞中的核因子-κB通路,抑制眼表细胞凋亡等机制发挥对干眼眼表炎症的治疗作用。目前局部使用他克莫司治疗干眼的研究主要为全身免疫疾病相关性干眼,包括慢性移植物抗宿主病、Sjogren综合征、瘢痕性类天疱疮、Steven-Johnson综合征等。

Dry eye disease(DED)is widely believed that immune-related inflammation plays an important role in its pathogenesis.Tacrolimus(FK506)has a certain therapeutic effect on ocular inflammation in dry eye by inhibiting calcineurin or MAPK pathway in T lymphocytes,NF-κB pathway in ocular surface cells,and apoptosis of ocular surface cells.Currently,studies on the topical use of tacrolimus in the treatment of dry eye have focused on dry eye with systemic immune diseases,including chronic graft-versus-host disease,Sjgren's syndrome,cicatoid pemphigoid,Steven-Johnson syndrome,etc.