海洋多肽的提取纯化及生物活性研究进展

Research Progress on Extraction, Purification and Biological Activity of Marine Peptides

海洋生物是人类重要的食物来源,其中含有大量高质量的蛋白质。海洋多肽具有抗高血压、抗氧化、抗肿瘤等生物学功能,作为开发功能性食品和药品的来源具有巨大的潜力。本文介绍了近年来国内外利用化学水解法、酶水解法、微生物发酵法以及物理辅助提取法提取海洋多肽并采用色谱法、膜分离法将其分离纯化的相关技术,比较了它们之间的差异性,并对海洋多肽的血管紧张素转换酶(ACE)抑制活性、抗氧化活性和抗肿瘤活性等生物活性以及应用现状进行了综述。

Marine life is an important food source for humans, which contains a lot of high-quality protein. Marine peptides have biological functions such as anti-hypertension, anti-oxidation, and anti-tumor. They have great potential as a source of functional foods and medicines. In this paper, the related technologies of chemical hydrolysis, enzymatic hydrolysis,microbial fermentation and physical-assisted extraction to extract marine polypeptides and to separate and purify them by chromatography and membrane separation are introduced, and the differences between them are compared. The biological activities and application status of marine peptides such as angiotensin converting enzyme(ACE) inhibitory activity,antioxidant activity and anti-tumor activity were reviewed.