胃癌组织FIBCD1、ANKRD49表达与临床病理特征和预后的关系研究

Relationship between expression of FIBCD1 and ANKRD49 in gastric cancer tissues with clinicopathological characteristics and prognosis

目的 分析胃癌组织中含纤维蛋白原C结构域蛋白1(FIBCD1)及锚蛋白重复结构域49 (ANKRD49)表达及与临床病理特征和预后的关系。方法 选取2015年1月至2018年1月该院收治的132例胃癌患者。以免疫组化染色法检测其胃癌组织和癌旁组织(距癌组织边缘2 cm以上)中FIBCD1、ANKRD49的表达情况。采用Spearman相关分析FIBCD1与ANKRD49的相关性。分析胃癌组织中FIBCD1、ANKRD49的表达与临床病理特征的关系。采用Kaplan-Meier生存曲线及Log-rank检验分析不同FIBCD1、ANKRD49表达情况胃癌患者生存情况。采用COX比例风险回归模型分析影响胃癌患者预后的危险因素。结果 胃癌组织中FIBCD1、ANKRD49阳性表达率显著高于癌旁组织(P<0.05)。胃癌组织中FIBCD1与ANKRD49表达呈正相关(r=0.522,P<0.001)。不同TNM分期、肿瘤浸润深度的患者胃癌组织中FIBCD1、ANKRD49阳性表达率差异均有统计学意义(P<0.05)。FIBCD1、ANKRD49阳性表达患者3年生存率均低于FIBCD1、ANKRD49阴性表达患者(P<0.05)。TNM分期Ⅲ期、肿瘤浸润深度T3~T4、FIBCD1阳性表达、ANKRD49阳性表达是影响胃癌患者预后的危险因素(P<0.05)。结论 胃癌组织中FIBCD1、ANKRD49阳性表达率升高,二者与TNM分期、肿瘤浸润深度有关,且可影响胃癌患者预后。

Objective To analyze the expressions of fibrinogen-containing C domain inclusion 1(FIBCD1) and ankyrin repeat domain 49(ANKRD49) in gastric cancer tissues and their relationship with clinicopathological characteristics and prognosis.Methods A total of 132 patients with gastric cancer treated in this hospital from January 2015 to January 2018 were selected.The immunohistochemical staining was used to detect the expressions of FIBCD1 and ANKRD49 in gastric cancer tissues and paracancerous tissues(more than 2 cm from the edge of cancer tissue).The correlation between FIBCD1 and ANKRD49 was analyzed by the Spearman correlation analysis.The relationship between the expression of FIBCD1 and ANKRD49 with the clinicopathological characteristics in gastric cancer tissues was analyzed.The Kaplan-Meier survival curve and Log-rank test were used to analyze the survival situation of gastric cancer patients with different expressions of FIBCD1 and ANKRD49.The COX proportional risk regression model was used to analyze the prognostic risk factors of gastric cancer patients.Results The positive expression rates of FIBCD1 and ANKRD49 in gastric cancer tissues were significantly higher than those in paracancerous tissues(P<0.05).FIBCD1 in gastric cancer tissues was positively correlated with ANKRD49 expression(r=0.522,P<0.001).The difference in the positive expression rates of FIBCD1 and ANKRD49 in gastric cancer tissues had statistical significance among the patients with different TNM stages and different tumor infiltration depth(P<0.05).The 3-year survival rates of the patients with FIBCD1 and ANKRD49 positive expression were lower than those in the patients with FIBCD1 and ANKRD49 negative expression(P<0.05).The TNM stage Ⅲ,tumor invasion depth T3-T4,positive expression of FIBCD1 and positive expression of ANKRD49 were the risk factors affecting the prognosis of the patients with gastric cancer(P<0.05).Conclusion The positive expression rates of FIBCD1 and ANKRD49 in gastric cancer tissues are increased, which are related to the TNM stage and tumor infiltration depth, moreover could affect the prognosis of the patients with gastric cancer.