尼麦角林联合盐酸美金刚对老年血管性痴呆患者的疗效

Efficacy of nimergoline combined with memantine hydrochloride in the treatment of elderly patients with vascular dementia

目的分析尼麦角林联合盐酸美金刚对老年血管性痴呆患者的疗效。方法将104例老年血管性痴呆患者随机分为观察组和对照组,每组52例。对照组给予尼麦角林治疗,观察组给予尼麦角林联合盐酸美金刚治疗。观察两组疗效、认知功能及生活能力、脑血流动力学指标及氧化应激反应指标水平。结果观察组总有效率高于对照组(P<0.05)。两组治疗前蒙特利尔认知评估量表(MoCA)、日常生活能力评定barthel指数评估量表(BI)评分比较,P>0.05,治疗后两组MoCA、BI评分均高于治疗前(P<0.05),且观察组高于对照组(P<0.05)。两组治疗前双侧大脑中动脉(MCA)、左右椎动脉(Va)、大脑后动脉(PCA)血流动力学水平比较,P>0.05,治疗后两组MCA、Va、PCA处血流动力学水平均高于治疗前(P<0.05),且观察组高于对照组(P<0.05)。两组治疗前血清超氧化物歧化酶(SOD)及丙二醛(MDA)水平比较,P>0.05,治疗后两组SOD水平高于治疗前,MDA水平低于治疗前(P<0.05),且观察组SOD水平高于对照组,MDA水平低于对照组(P<0.05)。结论尼麦角林联合盐酸美金刚治疗老年血管性痴呆能有效提升治疗效果,在改善脑血流的同时还能提升患者认知功能及生活能力,降低氧化应激反应。

Objective To explore the efficacy of nimergoline combined with memantine hydrochloride in the treatment of elderly patients with vascular dementia.Methods 104 elderly patients with vascular dementia were randomly divided into two groups,52 cases in each group.The control group was treated with niergoline,and the observation group was treated with niergoline combined with memantine hydrochloride.The therapeutic effect,cognitive function,life ability,cerebral hemodynamic index and oxidative stress response index level of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no statistically significant difference in scores of Montreal Cognitive Assessment Scale(MoCA)and the Barthel Index Evaluation Scale(BI)between the two groups before treatment(P>0.05).After treatment,the MoCA and BI scores of the two groups were higher than those before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the hemodynamic levels of bilateral middle cerebral artery(MCA),left and right vertebral artery(Va),and posterior cerebral artery(PCA)between two groups before treatment(P>0.05).After treatment,the MCA,Va,and PCA hemodynamic levels of the two groups were higher than those before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in serum superoxide dismutase(SOD)and malondialdehyde(MDA)levels between the two groups before treatment(P>0.05);the SOD level of the two groups after treatment was higher than that before treatment,and the MDA level was lower than that before treatment(P<0.05);the SOD level of the observation group was higher than that of the control group,and the MDA level was lower than that of the control group(P<0.05).Conclusion Niergoline combined with memantine hydrochloride can effectively improve the efficacy,the patients'cognitive function and living ability,the cerebral blood flow and reduce the oxidative stress response in the treatment of elderly patients with vascular dementia.