纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响

Effect of Naloxone Combined with Local Mild Hypothermia on Hypertensive Cerebral Hemorrhage and its Effect on Neurological Function Recovery and Cognitive Improvement

目的观察纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响。方法选取2020年6月-2021年6月我院治疗的84例高血压脑出血患者为研究对象,采用随机数字表法分为对照组和观察组,各42例。对照组给予纳络酮,观察组在对照组基础上给予局部亚低温治疗,比较两组脑水肿体积、神经功能恢复、认知改善情况、日常生活能力恢复情况及并发症发生情况。结果两组治疗后3 d、1周脑水肿体积均小于治疗前,且观察组小于对照组(P<0.05);两组治疗后NIHSS评分低于治疗前,MMSE评分高于治疗前,但观察组NIHSS评分低于对照组,MMSE评分高于对照组(P<0.05);观察组ADL优良率为88.10%,高于对照组的78.57%(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论纳络酮联合局部亚低温治疗高血压脑出血的疗效良好,可提高患者日常生活能力,降低神经功能缺损,减小脑水肿体积,提高患者认知功能,且不增加并发症发生几率,是一种安全、有效的治疗方法。

Objective To observe the therapeutic effect of naloxone combined with local mild hypothermia on hypertensive cerebral hemorrhage and its influence on the recovery of neurological function and cognitive improvement.Methods A total of 84 patients with hypertensive cerebral hemorrhage treated in our hospital from June 2020 to June 2021 were selected as the study subjects.They were divided into control group and observation group according to the random number table method,with 42 cases in each group.The control group was given naloxone,and the observation group was given local mild hypothermia treatment on the basis of the control group.The brain edema volume,neurological function recovery,cognitive improvement,daily living ability recovery and complications were compared between the two groups.Results The volume of cerebral edema at 3 days and 1 week after treatment in the two groups was smaller than that before treatment,and the observation group was smaller than the control group(P<0.05).After treatment,the NIHSS score of the two groups was lower than that before treatment,and the MMSE score was higher than that before treatment,but the NIHSS score of the observation group was lower than that of the control group,and the MMSE score was higher than that of the control group(P<0.05).The excellent and good rate of ADL in the observation group was 88.10%,which was higher than 78.57%in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Naloxone combined with local mild hypothermia is effective in the treatment of hypertensive cerebral hemorrhage,which can improve the daily living ability,reduce the neurological deficit and the volume of cerebral edema,improve the cognitive function,and do not increase the incidence of complications.It is a safe and effective treatment method.