血塞通注射液联合丁苯酞治疗急性脑梗死的效果及对患者神经功能的影响

Effect of Xuesaitong injection combined with butylphthalide in the treatment of acute cerebral infarction and its influence on neurological function of patients

目的探究血塞通注射液联合丁苯酞治疗急性脑梗死(ACI)的效果及对患者神经功能的影响。方法选取2019年11月至2020年11月本院收治的92例ACI患者作为研究对象,根据随机数字表法将其分为对照组(46例,丁苯酞)和观察组(46例,血塞通注射液联合丁苯酞)。比较两组的治疗效果。结果治疗2周后,两组的总胆固醇(TC)、甘油三酯(TG)、C反应蛋白(CRP)及低密度脂蛋白胆固醇(LDL-C)水平低于治疗前,且观察组低于对照组(P<0.05)。治疗2周后,两组的凝血酶时间(TT)、凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)长于治疗前,纤维蛋白原(Fbg)水平低于治疗前,且观察组优于对照组(P<0.05)。治疗2周后,两组的表观弥散系数(ADC)值高于治疗前,且观察组高于对照组(P<0.05)。治疗2周后,两组的美国国立卫生研究院卒中量表(NIHSS)评分低于治疗前,简易精神状态检查量表(MMSE)及蒙特利尔认知评估量表(MoCA)评分高于治疗前,且观察组优于对照组(P<0.05)。治疗2周后,两组的颈动脉不稳定斑块数量少于治疗前,且观察组少于对照组(P<0.05)。结论血塞通注射液联合丁苯酞治疗ACI患者安全有效,有利于改善血脂指标水平及凝血功能,促进神经功能、认知功能的恢复,并加强颈动脉斑块稳定性,值得临床推广与应用。

Objective To explore the effect of Xuesaitong injection combined with butylphthalide in the treatment of acute cerebral infarction(ACI)and its influence on neurological function of patients.Methods A total of 92 patients with ACI admitted in our hospital from November 2019 to November 2020 were selected as the research objects and divided into control group(46 cases,butylphthalide)and observation group(46 cases,Xuesaitong injection combined with butylphthalide)according to the random number table method.The treatment effects of the two groups were compared.Results After 2 weeks of treatment,the levels of total cholesterol(TC),triglyceride(TG),C-reactive protein(CRP)and low-density lipoprotein cholesterol(LDL-C)in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After 2 weeks of treatment,thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)of the two groups were longer than those before treatment,fibrinogen(Fbg)level was lower than that before treatment,and those of the observation group were better than the control group(P<0.05).After 2 weeks of treatment,the apparent diffusion coefficient(ADC)value of the two groups was higher than that before treatment,and that of the observation group was higher than the control group(P<0.05).After 2 weeks of treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the two groups was lower than that before treatment,the Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment Scale(MoCA)scores were higher than those before treatment,and those of the observation group were better than the control group(P<0.05).After 2 weeks of treatment,the number of carotid unstable plaques in the two groups was less than before treatment,and that in the observation group was less than the control group(P<0.05).Conclusion Xuesaitong injection combined with butylphthalide is safe and effective in the treatment of patients with ACI,it is beneficial to improve the levels of blood lipid indexes and coagulation function,promote the recovery of neurological function and cognitive function and strengthen the stability of carotid plaque,which is worthy of clinical promotion and application.