右佐匹克隆联合艾司西酞普兰、认知行为疗法治疗老年睡眠障碍伴抑郁的临床效果

Clinical effect of eszopiclone combined with escitalopram oxalate and cognitive behavior therapy on senile sleep disorder with depression

目的探讨右佐匹克隆联合艾司西酞普兰、认知行为疗法治疗老年睡眠障碍伴抑郁的临床效果。方法选择2018年9月至2020年11月收治的84例老年睡眠障碍伴抑郁患者为研究对象,根据随机数字表法将其分为对照组与观察组,各42例。对照组开展认知行为疗法联合艾司西酞普兰治疗,观察组在对照组基础上开展右佐匹克隆治疗。比较两组的治疗效果。结果治疗后,观察组的睡眠时间、睡眠质量、睡眠障碍、入睡时间及睡眠效率评分低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)、多巴胺(DA)水平高于对照组,差异具有统计学意义(P<0.05)。结论右佐匹克隆联合艾司西酞普兰、认知行为疗法可改善老年睡眠障碍伴抑郁患者的睡眠质量,减轻抑郁症状,调节神经因子水平。

Objective To explore the clinical effect of eszopiclone combined with escitalopram oxalate and cognitive behavior therapy on senile sleep disorder with depression.Methods Eighty-four elderly patients with sleep disorder and depression admitted from September 2018 to November 2020 were selected as the research objects and divided into control group and observation group according to random number table method,with 42 cases in each group.The control group was treated with cognitive behavior therapy combined with escitalopram oxalate,and the observation group was treated with eszopiclone on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the sleep time,sleep quality,sleep disorder,time before falling asleep and sleep efficiency scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of Hamilton Anxiety Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of 5-hydroxy tryptamine(5-HT),brain-derived neurotrophic factor(BDNF)and dopamine(DA)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Eszopiclone combined with escitalopram oxalate and cognitive behavior therapy can improve the sleep quality of elderly patients with sleep disorder and depression,relieve depressive symptomes,and regulate nerve factors levels.