蒙脱石散联合双歧杆菌活菌治疗小儿腹泻的临床效果及对消化功能的影响

Clinical effect of montmorillonite powder combined with Bifidobacterium viable bifidum in the treatment of pediatric diarrhoea and its influence on digestive function

目的探讨蒙脱石散联合双歧杆菌活菌治疗小儿腹泻的临床效果及对消化功能的影响。方法选取2016年1月至2021年1月我院收治的200例小儿腹泻患儿作为研究对象,将其随机分为对照组和观察组,各100例。对照组采用蒙脱石散治疗,观察组采用蒙脱石散联合双歧杆菌活菌治疗。比较两组的临床效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗3 d后,两组的双歧杆菌、乳酸杆菌数量多于治疗前,肠杆菌数量少于治疗前,且观察组优于对照组(P<0.05)。治疗5 d后,两组的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗5 d后,两组的胃泌素(GAS)、胃动素(MTL)、5-羟色胺(5-HT)水平低于治疗前,且观察组低于对照组(P<0.05)。治疗5 d后,两组的白细胞分化抗原3阳性(CD3+)、免疫球蛋白A(IgA)及免疫球蛋白G(IgG)水平、白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4+/CD8+)均高于治疗前,且观察组高于对照组(P<0.05)。结论蒙脱石散联合双歧杆菌活菌治疗小儿腹泻的临床效果显著,可改善患儿的胃动力情况及消化功能,调节胃肠微生物环境,且安全性高,值得临床推广。

Objective To investigate the clinical effect of montmorillonite powder combined with Bifidobacterium viable bifidum in the treatment of pediatric diarrhoea and its influence on digestive function.Methods A total of 200 children with pediatric diarrhea admitted in our hospital from January 2016 to January 2021 were selected as the research objects and randomly divided into control group and observation group,with 100 cases in each group.The control group was treated with montmorillonite powder,and the observation group was treated with montmorillonite powder combined with Bifidobacterium viable bacteria.The clinical effects of the two groups were compared.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After 3 d of treatment,the numbers of Bifidobacterium and Lactobacillus in the two groups were more than those before treatment,the number of Enterobacter was lower than that before treatment,and those in the observation group were better than the control group(P<0.05).After 5 d of treatment,the levels of tumor necrosis factor-α(TNF-α),interlukin(IL-6)and high-sensitivity C-reactive protein(hs-CRP)in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After 5 d of treatment,the levels of gastrin(GAS),motilin(MTL)and 5-hydroxy tryptamine(5-HT)in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After 5 d of treatment,the cluster of differentiation 3 positive(CD3+),immunoglobulin A(IgA),immunoglobulin G(IgG)levels and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4+/CD8+)in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05).Conclusion Montmorillonite powder combined with Bifidobacterium viable bacteria in the treatment of pediatric diarrhoea has a significant clinical effect,it can improve the gastric dynamics and digestive function of children,regulate the gastrointestinal microbial environment,with high safe,which is worthy of clinical promotion.