婴幼儿重症百日咳研究进展

Advances in research related to severe pertussis in infants and young children

百日咳是一种具有高度传染性的呼吸道疾病,尽管疫苗的广泛接种使得百日咳发病大幅度降低,但是近30年来出现了"百日咳再现",局部地区出现了百日咳暴发。未接种或未完成全程免疫接种的婴儿百日咳感染较重。由于小婴儿症状不典型易出现漏诊、误诊,不能及时诊治,易发展为重症百日咳,甚至死亡。因此,现就近年来重症百日咳的相关研究作一综述,为重症百日咳的临床诊治、预防和基础研究提供参考。

Pertussis is a highly contagious respiratory disease.Although widespread vaccination has greatly reduced the incidence of pertussis,there was a"recurrence of pertussis"in the past 30 years,and pertussis outbreaks occurred in some areas.Infants who have not been vaccinated or have not completed the full course of immunization suffer from more severe pertussis infections.Because of the atypical symptoms of young infants,missed diagnosis and misdiagnosis often occur,and pertussis cannot be diagnosed and treated in time.As a result,they can easily develop into severe pertussis or even die.In this article,recently published research on severe pertussis are summarized,so as to provide guidance for the clinical diagnosis,treatment,prevention and basic scientific research of severe pertussis.