多囊卵巢综合征患者并发症与贫血、子宫内膜厚度的关系

Correlation of Anemia,Endometrial Thickness and Complications in Patients with Polycystic Ovary Syndrome

目的分析多囊卵巢综合征(PCOS)患者并发症与贫血、子宫内膜厚度的相关性。方法选取郑州圣玛妇产医院2019年12月至2021年12月收治的出现并发症的PCOS患者126例纳入研究组,同期252例未出现并发症的PCOS患者被纳入对照组。比较两组临床资料,对差异有统计学意义的因素进行多因素logistic回归分析。结果两组抗米勒管激素(AMH)、卵巢动脉搏动指数(PI)、和肽素(CP)、血红蛋白(Hb)、子宫内膜厚度、胰岛素样生长因子1(IGF-1)、内脂素(VF)、睾酮(T)、C反应蛋白(CRP)、胰岛素抵抗(IR)指数相比,差异有统计学意义(P<0.05)。多因素logistic回归显示,AMH(>12.71μg·L^(-1))、CP(>13.22 pmol·L^(-1))、子宫内膜厚度(>8.83 mm)、VF(>59.48μg·L^(-1))、CRP(>5.78 mg·L^(-1))、IR(>3.81)是PCOS患者并发症的独立危险因素(P<0.05);Hb(>118.58 g·L^(-1))是PCOS患者并发症的独立保护因素(P<0.05)。结论PCOS患者出现并发症受子宫内膜厚度、CP、VF、IR水平等多种因素影响,临床医生可对患者进行多指标检测,对水平异常患者进行提前干预,以降低并发症风险。

Objective To analyze the correlation between anemia,endometrial thickness and complications in patients with polycystic ovary syndrome(PCOS).Methods A total of 126 PCOS patients with complications admitted to Zhengzhou Shengma Maternity Hospital from December 2019 to December 2021 were selected and included in the study group,and 252 PCOS patients without complications during the same period were included in the control group.The clinical data of the two groups were compared,and the factors with statistically significant differences were analyzed by multivariate logistic regression.Results There were statistical differences in the levels of anti-Miller tube hormone(AMH),ovarian artery pulsatility index(PI),copeptin(CP),hemoglobin(Hb),endometrial thickness,insulin-like growth factor 1(IGF-1),visfatin(VF),testosterone(T),C-reactive protein(CRP),and insulin resistance(IR)index between the two groups(P<0.05).Logistic regression analysis showed that AMH(>12.71μg·L^(-1)),CP(>13.22 pmol·L^(-1)),endometrial thickness(>8.83 mm),VF(>59.48μg·L^(-1)),CRP(>5.78 mg·L^(-1))and IR(>3.81)were independent risk factors for complications in patients with PCOS(P<0.05).Hb(>118.58 g·L^(-1))was an independent protective factor for complications in patients with PCOS(P<0.05).Conclusion Complications in patients with PCOS are influenced by various factors such as endometrial thickness,CP,VF,IR levels,etc.Clinicians can detect multiple indicators of patients and intervene patients with abnormal levels in advance to reduce the risk of complications.