ST段抬高型心肌梗死患者血清Gal-3、VEGF的表达及其与介入治疗预后的关系

Expression of Serum Gal-3 and VEGF in Patients with ST Segment Elevation Myocardial Infarction and Its Relationship with the Prognosis of Interventional Therapy

目的分析ST段抬高型心肌梗死(STEMI)患者血清半乳糖凝集素-3(Gal-3)、血管内皮生长因子(VEGF)表达及其与介入治疗后预后的关系。方法选取2018年8月至2020年8月就诊于信阳市第一人民医院的84例STEMI患者。所有患者均于介入治疗前测定血清Gal-3、VEGF水平,并在介入治疗后随访6个月,统计所有患者介入治疗后短期预后情况,分析STEMI患者血清Gal-3、VEGF表达及其与介入治疗后预后的关系。结果84例STEMI患者中,18例预后不良,占比为24.43%(18/84)。预后不良组血清Gal-3、VEGF水平较预后良好组高(P<0.05);两组发病至入院时间、体质量指数、梗死部位等资料比较,差异无统计学意义(P>0.05)。多因素logistic回归显示,血清Gal-3、VEGF水平升高与STEMI患者介入治疗后预后不良有关(OR>1,P<0.05)。受试者工作特征(ROC)曲线显示,血清Gal-3、VEGF水平单独及联合预测STEMI患者介入治疗后预后不良的曲线下面积(AUC)均>0.7,预测价值中等,联合预测价值最佳。结论血清Gal-3、VEGF水平与STEMI患者介入治疗后预后有关,血清Gal-3、VEGF水平升高可增加患者介入治疗后预后不良风险。

Objective To analyze the expression of serum galectin-3(Gal-3)and vascular endothelial growth factor(VEGF)in patients with ST segment elevation myocardial infarction(STEMI)and its relationship with the prognosis after interventional therapy.Methods A total of 84 patients with STEMI treated in the First People’s Hospital of Xinyang City from August 2018 to August 2020 were selected as the research subjects.The levels of serum Gal-3 and VEGF were measured before interventional therapy.Followed up for 6 months after interventional therapy,the short-term prognosis of all patients after interventional therapy was counted,and the expression of serum Gal-3 and VEGF in patients with STEMI and its relationship with the prognosis after interventional therapy were analyzed.Results Among 84 patients with STEMI,18 had poor prognosis,accounting for 24.43%(18/84).Levels of serum Gal-3 and VEGF in the poor prognosis group were higher than those in the good prognosis group(P<0.05).There was no significant difference in the time from onset to admission,body mass index and infarct location between the two groups(P>0.05).Multiple logistic regression analysis showed that elevated levels of serum Gal-3 and VEGF were related to poor prognosis in patients with STEMI after interventional therapy(OR>1,P<0.05).Receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of poor prognosis in patients with STEMI predicted by the levels of serum Gal-3 and VEGF alone and in combination were>0.7,all had medium prediction value,and the joint prediction value was the best.Conclusion The levels of serum Gal-3 and VEGF are related to the prognosis of patients with STEMI after interventional therapy.The increase of serum Gal-3 and VEGF levels can increase the risk of poor prognosis in patients after interventional therapy.