肺康复训练联合负氧离子吸入对慢性阻塞性肺疾病稳定期患者疗效及免疫功能的影响

Effects of Pulmonary Rehabilitation Training Combined with Negative Oxygen Ion Inhalation on Stable Chronic Obstructive Pulmonary Disease and Immune Function

目的 探讨肺康复训练联合负氧离子吸入治疗方案对慢性阻塞性肺疾病(COPD)稳定期患者临床效果及免疫功能的影响。方法 选择海南医学院第一附属医院2019年2~6月收治的140例COPD稳定期患者作为研究对象,根据随机数字法分为对照组和观察组,各70例。对照组接受单纯肺康复训练,观察组在此基础上联合负氧离子吸入治疗,治疗时长为3个月。比较两组肺功能[用力肺活量(FVC)、第1秒用力呼吸容积(FEV1)、FEV1占正常预计值百分比(FEV1%)]、呼吸肌功能[最大吸气压实测比值(MIP%)、最大呼气压实测比值(MEP%)]、运动耐量改善情况(6 min步行距离)、生活质量评分差异,检测外周血免疫球蛋白(Ig)A、IgG、IgM,T细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平,并进行统计学分析。结果 训练后两组肺功能FEV1、FVC、FEV1%、MIP%、MEP%均高于训练前,且观察组各指标均高于对照组,差异有统计学意义(P<0.05);在第1个月、2个月、3个月观察组6 min步行距离长于对照组(P<0.05);训练后两组生活质量评分均高于训练前,且观察组在生理功能、情感职能、健康变化维度评分高于对照组(P<0.05);训练后两组IgA、IgG、IgM及CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于训练前,且观察组各指标均高于对照组(P<0.05)。结论 对COPD稳定期患者采用肺康复综合训练联合负氧离子吸入方案进行治疗,可明显改善患者症状、提升生活质量、增强免疫功能。

Objective To investigate the effects of pulmonary rehabilitation training combined with negative oxygen ion inhalation on stable chronic obstructive pulmonary disease(COPD) and immune function.Methods A total of 140 stable COPD patients admitted to the First Affiliated Hospital of Hainan Medical College from February to June 2019 were selected in this study.The patients were divided into a control group and an observation group with 70 cases in each group according to the random number method.The control group received pulmonary rehabilitation training alone, and the observation group received pulmonary rehabilitation training in combination with negative oxygen ion inhalation.The treatment duration was 3 months.The lung function indices including forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and percentage of FEV1 to normal predicted value(FEV1%) were compared between the two groups.Respiratory muscle function indices including measured ratio of maximum inspiratory pressure(MIP%) and measured ratio of maximum expiratory pressure(MEP%) were compared between the two groups.Exercise tolerance index(such as 6-min walking distance) and quality of life scores were compared between the two groups.The level of peripheral immunoglobulin(Ig)(IgA,IgG,IgM),and T cell subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)) were determined.Results After training, FEV1,FVC,FEV1%,MIP%,and MEP% in the two groups were increased significantly, and the levels of these indices in the observation group were higher than those in the control group(P<0.05).The 6-min walking distance at month 1,2 and 3 of training in the observation group was longer than that in the control group(P<0.05).After training, the quality of life scores in the two groups were increased significantly, and the scores of physiological function, emotional function, and health changes in the observation group were higher than those in the control group(P<0.05).After training, the levels of IgA,IgG,and IgM;percentage of CD3^(+)and CD4^(+),and ratio of CD4^(+)/CD8^(+)in the two groups were increased significantly, and the levels of these indices in the observation group were higher than those in the control group(P<0.05).Conclusion Pulmonary rehabilitation comprehensive training combined with negative oxygen ion inhalation may significantly alleviate the symptoms, improve the quality of life and enhance immune function in patients with stable COPD.