丹参多酚酸盐对急性冠脉综合征患者血管内皮功能及血清超敏C反应蛋白与白细胞介素-6水平的影响

Effects of salvia miltiorrhiza polyphenolate on vascular endothelial function and serum levels of hypersensitive C-reactive protein and interleukin-6 in patients with acute coronary syndrome

目的探讨丹参多酚酸盐对急性冠脉综合征患者血管内皮功能及血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平的影响。方法选取2020年3月至2021年3月本院收治的175例急性冠脉综合征患者作为研究对象,按照随机数字表法分为实验组(n=88)与对照组(n=87),对照组给予常规治疗,实验组在对照组基础上联合丹参多酚酸盐治疗,比较两组临床疗效及治疗前后血清内皮素(ET-1)、循环内皮细胞(CEC)、血管假性血友病因子(VWF)、IL-6、hs-CRP、水平。结果实验组治疗总有效率为90.91%,高于对照组的75.86%,差异有统计学意义(P<0.05)。治疗前,两组VWF、ET-1、CEC水平比较差异无统计学意义;治疗后,两组VWF、ET-1、CEC水平均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-6、hs-CRP水平比较差异无统计学意义;治疗后,两组血清hs-CRP水平均低于治疗前,且实验组低于对照组,实验组血清IL-6水平低于治疗前,且低于对照组,差异有统计学意义(P<0.05),对照组治疗前后血清IL-6水平比较差异无统计学意义。结论丹参多酚酸盐治疗急性冠脉综合征效果显著,可降低患者血清hs-CRP、IL-6水平,减轻机体炎症反应,且可明显改善血管内皮功能,值得临床推广应用。

Objective To investigate the effects of salvia miltiorrhiza polyphenolate on vascular endothelial function and serum levels of hypersensitive C-reactive protein and interleukin-6 in patients with acute coronary syndrome.Methods 175 patients with acute coronary syndrome who were admitted to our hospital from March 2020 to March 2021 were selected as the research subjects,and they were divided into experimental group(n=88)and control group(n=87)according to the random number table method.The control group was given routine treatment,the experimental group was treated with salvia miltiorrhiza polyphenolate on the basis of the control group,and the clinical efficacy and the levels of serum endothelin1(ET-1),circulating endothelial cell(CEC),von willebrand factor(VWF),IL-6 and hs-CRP before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was 90.91%,which was higher than 75.86%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of VWF,ET-1 and CEC between the two groups;after treatment,the levels of VWF,ET-1 and CEC in the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of IL-6 and hs-CRP between the two groups;after treatment,the levels of serum hs-CRP in the two groups were lower than those before treatment,and the experimental group was lower than the control group,the level of serum IL-6 in the experimental group was lower than before treatment and lower than that in the control group,the difference was statistically significant(P<0.05),there was no significant difference in serum IL-6 levels in the control group before and after treatment.Conclusion Salvia miltiorrhiza polyphenolate has significant effect in the treatment of acute coronary syndrome,can reduce the serum hs-CRP and IL-6 levels,reduce the bodys'inflammatory response,and can significantly improve vascular endothelial function,which is worthy of clinical application.