凝血酶原时间和血小板参数检验在肝硬化患者肝损伤中的应用价值研究

Application value of prothrombin time and platelet parameters in liver injury in patients with cirrhosis

目的探究凝血酶原时间和血小板参数检验在肝硬化患者肝损伤中的临床应用价值。方法选取2018年7月至2020年7月于本院消化科就诊的92例肝硬化患者作为研究组,另选取同期92名健康者作为对照组。将研究组分为肝硬化损伤严重组(n=57)与肝硬化损伤轻微组(n=35)、癌变组(n=19)和非癌变组(n=62)。比较各组血小板压积(PCT)、血小板分布宽度(PDW)、平均血小板体积(MPV)、血小板计数(PLT)、国际标准化比值(INR)及凝血酶原时间。结果本研究组PCT和PLT均低于对照组,PDW、MPV、INR均高于对照组,凝血酶原时间长于对照组,差异有统计学意义(P<0.05)。肝脏损伤严重组PCT和PLT均低于肝脏损伤轻微组,PDW、MPV、INR均高于肝脏损伤轻微组,凝血酶原时间长于肝脏损伤轻微组,差异有统计学意义(P<0.05)。癌变组PCT和PLT均低于未癌变组,PDW、MPV、INR均高于未癌变组,凝血酶原时间长于未癌变组,差异有统计学意义(P<0.05)。结论PCT、PDW、MPV、PLT、INR及凝血酶原时间在诊断肝硬化及肝脏损伤程度方面具有较好的准确性,值得临床推广应用。

Objective To explore the clinical application value of prothrombin time and platelet parameters in liver injury in patients with cirrhosis.Methods 92 patients with cirrhosis treated in the Department of Gastroenterology of our hospital from July 2018 to July 2020 were selected as the study group,and 92 healthy persons were selected as the control group during the same period.The study group was divided into severe cirrhosis group(n=57),mild cirrhosis group(n=35),cancer group(n=19)and non-cancer group(n=62),the platelet hematocrit(PCT),platelet distribution width(PDW),mean platelet volume(MPV)and platelet count(PLT),international normalized ratio(INR)and prothrombin time were compared in each group.Results The PCT and PLT in the study group were lower than those in the control group,the PDW,MPV,INR were higher than those in the control group,and the prothrombin time was longer than that in the control group,and the difference was statistically significant(P<0.05).The PCT and PLT in the severe liver injury group were lower than those in the mild liver injury group,the PDW,MPV and INR were higher than those in the mild liver injury group,and the prothrombin time was longer than that in the mild liver injury group,and the difference was statistically significant(P<0.05).The PCT and PLT in the cancer group were lower than those in the non-cancer group,the PDW,MPV and INR were higher than those in the non-cancer group,and prothrombin time was longer than that in the non-cancer group,and the difference was statistically significant(P<0.05).Conclusion The PCT,PDW,MPV,PLT,INR and prothrombin time have good accuracy in the diagnosis of liver cirrhosis and liver injury,which is worthy of clinical application.