低分子肝素联合阿司匹林治疗子宫动脉血流阻力升高复发性流产的保胎效果观察

Observation on the effect of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion with increased uterine artery blood flow resistance

目的探究低分子肝素联合阿司匹林治疗子宫动脉血流阻力升高复发性流产的保胎效果。方法选取2019年1月至2021年12月本院收治的40例复发性流产患者作为研究对象,按照随机数字表法分为对照组和研究组,每组20例。对照组给予阿司匹林治疗,研究组在对照组基础上联合低分子肝素钙治疗,比较两组治疗前后子宫动脉血流阻力参数变化、妊娠活产率和不良反应发生情况。结果治疗前,两组动脉搏动指数(PI)、阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D)比较差异无统计学意义;治疗后,两组PI、RI和S/D均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组妊娠活产率为95.00%,高于对照组的70.00%,差异有统计学意义(P<0.05)。研究组不良反应发生率为10.00%,明显低于对照组的40.00%,差异有统计学意义(P<0.05)。结论低分子肝素联合阿司匹林治疗子宫动脉血流阻力升高复发性流产的保胎效果显著,可有效减小子宫动脉血流阻力,降低不良妊娠结局发生率,安全性较高,值得临床推广应用。

Objective To explore the effect of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion with increased uterine artery blood flow resistance.Methods 40 patients with recurrent abortion who were admitted to our hospital from January 2019 to December 2021 were selected as the research subjects,and they were divided into control group and study group according to the random number table method,with 20 cases in each group.The control group was treated with aspirin,and the study group was treated with low molecular weight heparin calcium on the basis of the control group.The changes of uterine artery blood flow resistance parameters before and after treatment,the pregnancy live birth rate and the occurrence of adverse drug reactions were compared between the two groups.Results Before treatment,there was no significant difference in pulsatility index(PI),resistance index(RI),peak systolic velocity/end diastolic velocity(S/D)between the two groups;after treat ment,the PI,RI and S/D in the two groups were lower than before treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05).The live birth rate of pregnancy in the study group was 95.00%,which was higher than 70.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 10.00%,which was significantly lower than 40.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Low molecular weight heparin combined with aspirin in the treatment of recurrent abortion with increased uterine artery blood flow resistance has significant effect of preserving pregnancy,can effectively reduce the uterine artery blood flow resistance,and reduce the occurrence of adverse pregnancy outcomes,it has high safety and is worthy of clinical application.