硫酸镁、硝苯地平和拉贝洛尔联合治疗先兆子痫的效果观察

Effect of magnesium sulfate combined with nifedipine and labetalol in the treatment of preeclampsia

目的讨论硫酸镁、硝苯地平和拉贝洛尔联合治疗先兆子痫的临床效果。方法抽取漯河市第三人民医院2020年2月至2021年2月收治的80例先兆子痫患者,按随机数字表法分为对照组和观察组,每组40例。对照组给予硫酸镁联合硝苯地平注射治疗,观察组在对照组治疗基础上加用拉贝洛尔治疗。观察比较两组患者的治疗效果,治疗前后血压水平、24 h尿蛋白、血流动力学指标[中心静脉压(CVP)、左心室功率(LVW)以及心脏指数(CI)],比较两组不良妊娠结局发生率。结果观察组治疗有效率(85.00%,34/40)高于对照组(62.50%,25/40),P<0.05。治疗后,两组患者舒张压、收缩压、24 h尿蛋白水平较治疗前下降,且与对照组比较,观察组舒张压、收缩压、24 h尿蛋白水平下降更明显(P<0.05);治疗后,两组患者CVP、LVW、CI水平均上升,且与对照组比较,观察组CVP、LVW、CI水平较高(P<0.05);治疗后,观察组胎儿不良结局发生率(2/40,5.00%)低于对照组(13/40,32.50%),P<0.05。结论硫酸镁、硝苯地平、拉贝洛尔联合治疗先兆子痫患者的疗效较好,能有效控制血压并减少尿蛋白,改善妊娠结局。

Objective To discuss the effect of magnesium sulfate combined with nifedipine and labetalol in the treatment of preeclampsia.Methods Eighty patients with preeclampsia treated in the Third People’s Hospital of Luohe from February 2020 to February 2021 were selected,and they were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with magnesium sulfate combined with nifedipine,and the observation group was treated with labetalol based on the treatment of the control group.The curative effect of the two groups were compared;blood pressure status,24-hour urinary protein,hemodynamics including central venous pressure(CVP),left ventricular power(LVW)and cardiac index(CI)of the two groups were compared before and after treatment;and adverse pregnancy outcomes were compared between the two groups.Results The effective rate of the observation group(85.00%,34/40)was higher than that of the control group(62.50%,25/40),P<0.05.After treatment,the levels of diastolic blood pressure,systolic blood pressure and 24 h urinary protein in the two groups decreased,compared with those before treatment,and the levels of diastolic blood pressure,systolic blood pressure and 24 h urinary protein in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CVP,LVW and CI in the two groups increased,compared with those before treatment,and the levels of CVP,LVW and CI in the observation group were higher than those in the control group(P<0.05).After treatment,the incidence of adverse fetal outcomes in the observation group(2/40,5.00%)was lower than that in the control group(13/40,32.50%),P<0.05.Conclusions In the treatment of preeclampsia,magnesium sulfate combined with nifedipine and labetalol has better clinical efficacy,it can effectively control blood pressure,reduce urinary protein,and improve pregnancy outcome.