巨噬细胞在代谢相关脂肪性肝病中作用机制的研究进展

Research progress on the mechanism of macrophages in metabolic associated fatty liver disease

代谢相关脂肪性肝病(MAFLD)全球患病率日趋上升,现如今MAFLD已成为一个全球性的健康问题。巨噬细胞具有清除病原微生物、抗原呈递、促进或抑制肝脏炎症反应的能力,直接参与肝脏疾病的发生发展和损伤修复。巨噬细胞在MAFLD中的作用机制及其临床意义逐渐成为当下的医学研究热点。最新研究表明,巨噬细胞或将成为MAFLD新的治疗手段和治疗靶点。本文就巨噬细胞的分型、功能及其在MAFLD发病不同阶段中的作用进行探讨和归纳,旨在为临床预防和治疗MAFLD提供相关思路与新视角。

The global prevalence of metabolic associated fatty liver disease(MAFLD)is on the rise,and MAFLD has now become a global health problem.Macrophages have the ability to scavenge pathogenic microorganisms,antigen presentation,and promote or inhibit the hepatic inflammatory response and are directly involved in the development of liver diseases and injury repair.The mechanism of macrophage in MAFLD and its clinical significance have gradually become a current medical research hotspot.Recent studies have shown that macrophages may become new therapeutic tools and therapeutic targets for MAFLD.In this paper,the classification and function of macrophages and their role in different stages of MAFLD pathogenesis are discussed and summarized in order to provide relevant ideas and new perspectives for clinical prevention and treatment of MAFLD.