基于CiteSpace的特发性肺纤维化生物标志物研究热点与趋势可视化分析

Visualization analysis of research hotspots and trends of biomarkers for idiopathic pulmonary fibrosis based on CiteSpace

目的基于CiteSpace软件总结特发性肺纤维化(IPF)中生物标志物研究的热点与趋势。方法检索2001年1月至2021年8月CNKI和Web of Science中关于IPF生物标志物的文献,以作者、机构和关键词为节点,采用CiteSpace 5.7.R2软件进行可视化分析。结果共纳入文献507篇。国内外发文量均呈上升趋势,国内该领域研究的作者、机构较少且相对分散,国外作者、机构较多且合作较为密切。国内外研究热点主要包括基因多态性、蛋白、诊断及预后标志物等,研究趋势为诊断和预后标志物。结论国内各作者或机构应加强学术交流与合作,进一步深入研究该领域的热点与趋势,为IPF的临床诊疗提供参考。

Objective To summarize the research hotspots and trends of biomarkers in idiopathic pulmonary fibrosis(IPF)based on CiteSpace software.Methods Literatures on IPF biomarkers in CNKI and Web of Science from January 2001 to August 2021 was retrieved,with authors,institutions,and keywords as nodes,and CiteSpace 5.7.R2 software was used for visual analysis.Results A total of 507 literatures were included.The number of published literatures at home and abroad was on the rise.There were few and relatively scattered authors and institutions in this field in China.There were many foreign authors and institutions with close cooperation.The research hotspots at home and abroad included gene polymorphisms,proteins,diagnostic,and prognostic biomarkers.The research trends included diagnostic and prognostic biomarkers.Conclusion Domestic authors or institutions should strengthen academic exchanges and cooperation,further study the hot spots and trends in this field,and provide reference for the clinical diagnosis and treatment of IPF.