卡介苗多糖核酸配合光动力疗法对女性外生殖器尖锐湿疣患者的效果及免疫功能的影响

Effect of BCG polysaccha-ride nucleic acid combined with photodynamic therapy and its influence on immune function of patients with condyloma acuminatum of femal external genitalia

目的探讨卡介苗多糖核酸配合光动力疗法对女性外生殖器尖锐湿疣患者的效果及免疫功能的影响。方法选择2020年1月至12月江苏省淮安市第四人民医院就诊的84例女性外生殖器尖锐湿疣患者为研究对象,依照数字奇偶法将其分为对照组(42例)和研究组(42例)。对照组给予光动力疗法,研究组在此基础上接受卡介苗多糖核酸治疗,两组治疗时间均为6个月。比较两组临床疗效。比较两组治疗前后血清肿瘤坏死因子-α(TNF-α)、转化生长因子β1(TGF-β1)及CD3^(+)、CD4^(+)、CD8^(+)T细胞水平。记录两组不良反应发生情况。随访1年,比较两组复发率。结果研究组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清TGF-β1及CD3^(+)、CD4^(+)T细胞水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清TNF-α、CD8^(+)T细胞水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗期间两组不良反应总发生率比较,差异无统计学意义(P>0.05)。随访1年,研究组失访1例,对照组失访2例,整体随访率为96.43%,研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论卡介苗多糖核酸配合光动力疗法治疗女性外生殖器尖锐湿疣患者效果确切,可减轻机体炎症反应,改善免疫功能,安全可靠,且预后良好。

Objective To investigate the effect of BCG polysaccha-ride nucleic acid combined with photodynamic therapy and its influence on immune function of patients with condyloma acuminatum of female external genitalia.Methods A total of 84 patients with condyloma acuminatum of organ external genitalia treated in the Fourth People’s Hospital of Huaian City,Jiangsu Province from January to December 2020 were selected as the research objects and divided into the control group(42 cases)and the study group(42 cases)according to the parity method.The control group was treated with photodynamic therapy,and the study group was treated with BCG polysaccha-ride nucleic acid on this basis.The treatment time in both groups was six months.The clinical efficacy of the two groups was compared.The levels of serum tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1),CD3^(+),CD4^(+),and CD8^(+)T cells were compared between the two groups before and after treatment.The occurrence of adverse reactions in the two groups was recorded.The recurrence rate was compared between the two groups after one year follow-up.Results The efficacy of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum TGF-β1 and CD3^(+),CD4^(+)T cells in the two groups were higher than those before treatment,and the study group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum TNF-αand CD8^(+)T cells in the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).After one year of follow-up,one case in the study group and two cases in the control group were lost to follow-up.The overall follow-up rate was 96.43%.The recurrence rate in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion BCG polysaccha-ride nucleic acid combined with photodynamic therapy in the treatment of fpatients with condyloma acuminatum of female external genitalia is effective,which can reduce the body’s inflammatory response,improve immune function,safe and reliable,and the prognosis is good.