血清sTREM-1、MCP-1、hs-CRP水平检测对老年急性心肌梗死患者PCI术后再狭窄的预测价值

Predictive value of serum sTREM-1,MCP-1,and hs-CRP levels in restenosis after PCI in elderly patients with acute myocardial infarction

目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)、单核细胞趋化蛋白1(MCP-1)、超敏C反应蛋白(hs-CRP)水平检测对老年急性心肌梗死患者经皮冠脉介入术(PCI)术后再狭窄的预测价值。方法选取2018年3月至2021年3月江苏省无锡市第二人民医院收治98例老年急性心肌梗死患者。术后均随访6个月,根据再狭窄发生情况将受试者分为再狭窄组、非再狭窄组。分析PCI术后再狭窄发生的危险因素;不同指标预测老年急性心肌梗死患者PCI术后再狭窄的诊断效能采用受试者操作特征(ROC)曲线。结果98例患者发生再狭窄的有11例,发生率为11.22%。再狭窄组sTREM-1、MCP-1、hs-CRP高于非再狭窄组(P<0.05)。sTREM-1、MCP-1、hs-CRP是老年急性心肌梗死患者PCI术后发生再狭窄的危险因素(OR=3.770、5.376、6.241,P<0.05)。sTREM-1、MCP-1、hs-CRP联合预测老年急性心肌梗死患者PCI术后再狭窄发生的曲线下面积高于各指标单独预测(P<0.05)。结论血清sTREM-1、MCP-1、hs-CRP与老年急性心肌梗死患者PCI术后再狭窄相关,联合检测的预测效能更佳。

Objective To investigate the predictive value of serum soluble triggering receptor expresses on myeloid cells-1(sTREM-1),monocytogenic protein 1(MCP-1),and hypersensitivity C reactive protein(hs-CRP)levels after percutaneous coronary intervention(PCI)in elderly patients with acute myocardial infarction.Methods A total of 98 elderly patients with acute myocardial infarction admitted to Wuxi Second People’s Hospital of Jiangsu Province from March 2018 to March 2021 were selected.All subjects were followed up for six months.According to the incidence of restenosis,thy were divided into restenosis group and non-restenosis group.The risk factors of restenosis after PCI were analyzed;the receiver operating characteristic(ROC)curve was used to predict the diagnostic efficacy of different indicators for restenosis after PCI in elderly patients with acute myocardial infarction.Results Restenosis occurred in 11 of 98 patients,with an incidence of 11.22%.The levels of sTREM-1,MCP-1,and hs-CRP in restenosis group were higher than those in non-restenosis group(P<0.05).sTREM-1,MCP-1,and hs-CRP were risk factors for restenosis after PCI in elderly patients with acute myocardial infarction(OR=3.770,5.376,6.241,P<0.05).The area under the curve of sTREM-1,MCP-1,and hs-CRP combined in predicting restenosis after PCI in elderly patients with acute myocardial infarction was higher than that predicted by each index alone(P<0.05).Conclusion Serum sTREM-1,MCP-1,and hs-CRP are all associated with restenosis after PCI in elderly patients with acute myocardial infarction,and the predictive efficacy of the combination test is better.