咖啡因对早产儿支气管肺发育不良的预防效果及对血管内皮生长因子水平的影响

Preventive effect of Caffeine on bronchopulmonary dysplasia in premature infants and its influence on the level of vascular endothelial growth factor

目的探讨咖啡因对早产儿支气管肺发育不良(BPD)的预防效果及对血管内皮生长因子(VEGF)水平的影响。方法选取2020年5月至2021年4月邵阳学院附属第一医院新生儿科收治的42例早产儿作为研究对象,按照随机数字表法分为治疗组和对照组,每组21例。对照组给予常规对症处理,治疗组在对照组的基础上给予咖啡因治疗。比较两组早产儿的住院时间、体重增长速率、需氧时间、BPD发病率、死亡率以及出生后第1、3、7、14、21天时外周血血清中VEGF的表达水平。结果治疗组早产儿的住院时间和需氧时间均短于对照组,体重增长速率快于对照组,BPD发病率低于对照组,差异有统计学意义(P<0.05)。两组早产儿的死亡率比较,差异无统计学意义(P>0.05)。治疗组早产儿第7、14、21天血清中的VEGF表达水平均低于对照组,差异有统计学意义(P<0.05)。结论VEGF的表达水平与咖啡因治疗BPD时间相关,有一定的临床意义。

Objective To investigate the preventive effect of Caffeine on bronchopulmonary dysplasia(BPD)in premature infants and its influence on the level of vascular endothelial growth factor(VEGF).Methods A total of 42 premature infants treated in the Department of Neonatal Pediatrics of the First Affiliated Hospital of Shaoyang University from May 2020 to April 2021 were selected as the research objects,according to random number table method,they were divided into the treatment group and the control group,with 21 cases in each group.The control group was treated with routine symptomatic treatment,and the treatment group was treated with Caffeine on the basis of the control group.The hospitalization time,weight growth rate,aerobic time,incidence rate of BPD,mortality rate,and the expression level of VEGF in peripheral blood serum on 1,3,7,14,21 d after birth of the two groups were compared.Results The hospitalization time and aerobic time of the premature infants in the treatment group were shorter than those in the control group,the weight growth rate in the treatment group was faster than that in the control group,he incidence rate of BPD in the treatment group was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in mortality between the treatment group and the control group(P>0.05).At the three time points of 7,14,21 d,the expression level of VEGF in the serum of premature infants in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The expression level of VEGF is related to the time of Caffeine treatment of BPD,which has a certain clinical significance.