雌激素、雄激素及其受体对子宫内膜影响的研究进展

Research progress on the effects of estrogen,androgen and their receptors on the endometrium

雌激素和雄激素等甾体激素的受体广泛分布于子宫内膜中,对内膜的生理功能产生调控,并在子宫内膜异位症、肿瘤等病理性改变中发挥作用。雌激素合成所需的芳香化酶和硫酸酯酶等对内膜功能影响巨大,而不同类型雌激素受体的时空表达特点各异,可能分别介导内膜中血管内皮细胞、免疫细胞、上皮和间质细胞之间的相互作用。雄激素受体则主要调控子宫内膜上皮和间质细胞通讯、经期内膜修复和细胞增殖。文章就雌激素、雄激素及其受体对子宫内膜影响的研究进展作一综述,旨在为改善子宫内膜病理变化、加快组织修复、阻断子宫内膜异位症和子宫内膜癌等提供新的方法和药物靶点。

The receptors for steroid hormones such as estrogen and androgen are widely distributed in the endometrium,which regulates the physiological functions of the endometrium and plays a role in pathological changes such as endometriosis and tumors.The aromatase and sulfatase required for estrogen synthesis have a huge impact on the function of the intima,and the expression characteristics of different types of estrogen receptors are different in time and space,which may mediate the vascular endothelial cells,immune cells,and epithelium in the intima respectively.and interstitial cells.Androgen receptors mainly regulate endometrial epithelial and stromal cell communication,menstrual endometrial repair,and cell proliferation.This article reviews the research progress on the effects of estrogen,androgen and their receptors on the endometrium,aiming to improve endometrial pathological changes,accelerate tissue repair,and block endometriosis and endometrial cancer.etc.provide new methods and drug targets.