C-反应蛋白/白蛋白比值、单核细胞/淋巴细胞比值在肺结核患者中的应用价值

Application value of C-reactive protein/albumin ratio and monocyte/lymphocyte ratio in patients with pulmonary tuberculosis

目的 探讨C-反应蛋白/白蛋白比值及单核细胞/淋巴细胞比值等感染性指标在肺结核诊断中的应用价值。方法 收集2021年1月—11月入院的肺结核患者131例,收集同期非结核性肺炎患者103例,在患者入院24 h内采集标本,分别做外周血细胞、C-反应蛋白及白蛋白等指标检测。结果 肺结核组与健康对照组相比中性粒细胞、单核细胞、C-反应蛋白、NLR、CAR、MLR升高,淋巴细胞、白蛋白值降低;与肺炎组相比白细胞和淋巴细胞、NLR降低,MLR升高;肺结核组治疗后,中性粒细胞、CRP、NLR、 CAR、MLR下降,淋巴细胞升高。由ROC曲线分析显示,中性粒细胞曲线下面积为0.701、CRP曲线下面积为0.681、白蛋白曲线下面积为0.270、CAR曲线下面积为0.696、NLR曲线下面积为0.738、MLR曲线下面积为0.752。结论 中性粒细胞、CRP、CAR、NLR、MLR等指标的联合应用,对肺结核的诊断、病情活动及疗效评估有较大的应用价值。

Objective To investigate the value of infectivity index like C-reactive protein/albumin ratio and monocyte/lymphocyte ratio in the diagnosis of pulmonary tuberculosis.Methods Totally,131 patients with pulmonary tuberculosis and 103patients with non-tuberculous pneumonia in the same period from January to November 2021 were collected.The blood was collected within 24 hours after admission,and peripheral blood cells,C-reactive protein and albumin were detected.Results Compared with the control group,neutrophils,monocytes,C-reactive protein,NLR,CAR and MLR were increased in pulmonary tuberculosis group,while lymphocyte and albumin values were decreased.Compared with pneumonia group,leukocyte,lymphocyte and NLR decreased,while MLR increased.After treatment,neutrophils,CRP,NLR,CAR and MLR decreased,while lymphocytes increased.ROC curve analysis showed that the area under the ROC curve was 0.701 for neutrophil,0.681 for CRP,0.270 for albumin,0.696 for CAR,0.738 for NLR,and 0.752 for MLR.Conclusion The combined application of neutrophil,CRP,CAR,NLR,MLR and other indicators has great application value in the diagnosis,disease activity and curative effect evaluation of pulmonary tuberculosis.