补肾温阳止痛汤联合推拿治疗腰椎骨质增生临床研究

Clinical Study on Bushen Wenyang Zhitong Tang Combined with Tuina for Lumbar Hyperosteogeny

目的:观察补肾温阳止痛汤联合推拿治疗腰椎骨质增生的临床疗效。方法:选取腰椎骨质增生患者100例,按随机数字表法分为治疗组和对照组各50例。2组入院后均给予常规治疗,对照组在此基础上给予推拿治疗,治疗组在对照组的基础上给予补肾温阳止痛汤治疗。观察2组临床疗效,以及治疗前后中医症状评分、疼痛程度、腰椎功能及生化指标变化。结果:治疗组临床总有效率为94.00%,优于对照组的76.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状体征各项评分均低于治疗前(P<0.05),且治疗组各项症状体征评分均低于对照组(P<0.05)。治疗后,2组疼痛视觉模拟评分法(VAS)评分、Oswestry功能障碍指数问卷(ODI)评分均低于治疗前(P<0.05),且治疗组VAS、ODI评分均低于对照组(P<0.05)。治疗后,治疗组血清血栓素B2(TXB2)水平低于治疗前(P<0.05),血清6-酮-前列腺素F1α(6-K-PGF1α)水平高于治疗前(P<0.05),且治疗组2项指标改善较对照组更显著(P<0.05);对照组治疗前后血清TXB2、6-K-PGF1α水平比较,差异均无统计学意义(P>0.05)。结论:补肾温阳止痛汤联合推拿治疗腰椎骨质增生疗效显著,可有效调节血清TXB2、6-K-PGF1α水平,减轻疼痛,显著改善腰椎功能。

Objective:To observe the clinical effect of Bushen Wenyang Zhitong tang combined with tuina for lumbar hyperosteogeny.Methods:A total of 100 cases of patients with lumbar hyperosteogeny were selected and divided into the treatment group and the control group according to the random number table method,with 50 cases in each group.After admission,both groups were given routine treatment;the control group was additionally treated with tuina,and the treatment group was additionally treated with Bushen Wenyang Zhitong tang based on the treatment of the control group.The clinical effects as well as the changes in Chinese medicine symptom scores,pain degree,lumbar function and biochemical indexes before and after treatment in the two groups were observed.Results:The total clinical effective rate was94.00% in the treatment group,better than that of 76.00% in the control group,the difference being significant(P<0.05).After treatment,all scores of symptoms and signs in the two groups were lower than those before treatment(P<0.05),and each score of symptoms and signs in the treatment group was lower than that in the control group(P<0.05).After treatment,the scores of Visual Analogue Scale(VAS) and Oswestry Disability Index(ODI) in the two groups were lower than those before treatment(P<0.05),and the scores of VAS and ODI in the treatment group were lower than those in the control group(P<0.05).After treatment,the level of serum thromboxane B2(TXB2) in the treatment group was lower than that before treatment(P<0.05),and the level of serum 6-keto-prostaglandin F1α(6-K-PGF1α) was higher(P<0.05),and the improvement of the two indexes in the treatment group was more significant than that in the control group(P<0.05).There was no significant difference being found in the comparison of the levels of TXB2 and6-K-PGF1α in serum before and after treatment in the control group(P>0.05).Conclusion:The therapy of Bushen Wenyang Zhitong tang combined with tuina for lumbar hyperosteogeny has a significant curative effect,and can effectively regulate the levels of TXB2 and 6-K-PGF1α in serum,alleviate pain,significantly improve lumbar function.