基于数据挖掘研究冯志荣治疗恶性肿瘤用药规律

Study on Administration Rules of FENG Zhirong in Treating Malignant Tumor Based on Data Mining

目的:基于数据挖掘研究总结冯志荣治疗恶性肿瘤的用药规律。方法:拟定处方纳入标准和排除标准,收集2017年1月1日—2019年12月31日冯志荣名老中医治疗恶性肿瘤的病历,建立处方数据库。运用Excel进行药物频数及频率统计,提取高频药物;运用SPSS18.0软件对高频药物进行关联规则Apriori算法,挖掘常用药对;运用SPSS Statistics 22.0对高频药物进行因子分析,挖掘核心药物组合;并通过对冯志荣名老中医进行访谈交流,对分析结果进行修正补充。结果:纳入处方686张,涉及中药238味,累计用药频数为10973次,高频中药(频数≥70)30味。高频药物关联分析共得到药物关联规则88条,具有较高临床价值的中药药对20对。因子分析提取出公因子10个,累计方差贡献率65.508%。结论:冯志荣名老中医治疗恶性肿瘤以扶正抗癌为基本治则,临床辨证与辨病相结合,参考现代药理研究结果,精准用药,并重视使用药对治疗复杂多变的兼症。

Objective:To study the administration rules of FENG Zhirong in treating malignant tumor based on data mining.Methods:The inclusion and exclusion criteria for prescriptions was drew up.The medical records of malignant tumors treated by FENG Zhirong,a famous and experienced Chinese medicine physician,from January 1,2017 to December 31,2019,were collected to establish a prescription database.Medicinals frequency was counted by Excel to extract high-frequency medicinals.SPSS18.0 software was used to mine common couplet medicinals by using Apriori algorithm of association rules for high-frequency medicinals;SPSS Statistics 22.0 was used for factor analysis of high-frequency medicinals to mine core medicinal combinations;through the interview and exchange with FENG Zhirong,the analysis results were revised and supplemented.Results:A total of 686 prescriptions were included,involving 238 medicinals,with a cumulative frequency of 10,973 times and 30 high-frequency medicinals(frequency greater than or equal to 70).A total of 88 medicinal association rules were obtained by highfrequency medicinal association analysis,including 20 couplet medicinals with high clinical value.Ten common factors was extracted by factor analysis,and the cumulative variance contribution rate was 65.508%.Conclusion:In the treatment of malignant tumor,FENG Zhirong follows the basic treatment principle of reinforcing healthy qi to fight against cancer,combines clinical syndrome differentiation with disease identification,uses medicinals accurately with reference to the results of modern pharmacological research,and attaches importance to the use of mdicinals to treat complex and changeable concurrent diseases.