关注胃肠道黏膜屏障,规范黏膜保护剂应用——《胃肠道黏膜保护临床专家共识(2021年,福州)》解读

Gastrointestinal Mucosal Barrier and Standardization of the Application of Mucosal Protective Agents:Interpretation on the Consensus of Clinical Experts on Gastrointestinal Mucosal Protection(2021,Fuzhou)

胃肠道是人体与外界相通的最大器官,其黏膜不仅是机体与外界联系的重要屏障,也是胃肠道各种功能得以正常维持的基础。胃肠道黏膜屏障功能是胃肠道疾病发生发展的共同病理生理基础。目前,针对胃肠道黏膜,尤其是小肠黏膜仍缺乏深入系统的认识,临床实践中更多关注损伤因子的作用,忽略了黏膜防护的重要性。为提高医务人员对胃肠道黏膜保护的认识,规范黏膜保护剂的应用,中华医学会消化病学分会胃肠激素与黏膜屏障学组制定了我国第一部胃肠道黏膜保护专家共识,于2021年底正式发布。本文针对共识制定的背景、过程和主要内容进行解读,以帮助医务人员提高认识,规范临床诊疗。

The gastrointestinal tract is the largest organ connecting the human body and the outside world.The gastrointestinal mucosa is not only an important barrier connecting the internal body and the outside world,but also plays a key role in maintaining normal functions of the gastrointestinal tract.The injuries of gastrointestinal mucosal barrier are the common pathogenesis mechanisms in the occurrence and development of gastrointestinal diseases.However,there is still a lack of deep and systematic understanding of gastrointestinal mucosa,especially small intestinal mucosa.In clinical practice,more attentions have been paid to the role of injury factors,but the importance of mucosal protection is ignored.In order to improve the understanding of gastrointestinal mucosa protection and standardize the clinical application of gastrointestinal mucosal protective agents,the Gastrointestinal Hormone and Mucosal Barrier Group,Chinese Society of Gastroenterology,Chinese Medical Association formulated the first expert consensus on gastrointestinal mucosal protection in China,which was offi-cially published at the end of 2021.This paper interprets the background,process and main content of this consensus,so as to raise awareness among medical staff,and standardize clinical diagnosis and treatment.