PM_(2.5)暴露致肺上皮细胞恶性转化机制研究进展

Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM_(2.5) exposure

空气细颗粒物(PM_(2.5))在环境污染和公众健康领域越来越受到重视。研究发现,PM_(2.5)可被人体吸入并沉积在气道和肺泡,甚至通过血液扩散到全身组织器官之后产生毒性效应。PM_(2.5)长期暴露导致的肺上皮细胞恶性转化在肺癌的发生发展中起着重要作用。本文回顾了近年来关于PM_(2.5)暴露导致肺上皮细胞恶性转化的机制研究;论述了主要生物学机制,包括表观遗传学、肿瘤微环境及其他生物学途径的改变;提出了进一步研究PM_(2.5)暴露引起肺上皮细胞恶性转化的可能的研究方向;以期为公众健康管理和空气环境质量评价提供科学的依据和参考。

Fine particulate matter(PM_(2.5))has attracted more and more attention in the field of environmental pollution and public health.Previous studies have found that PM_(2.5)can be inhaled and deposit in the airway and alveoli,and even spread to the whole-body tissues and organs through blood,resulting in various toxic effects.The malignant transformation of lung epithelial cells associated with long-term exposure to PM_(2.5)may play an important role in the occurrence and development of lung cancer.This paper reviewed recent studies on the mechanisms of malignant transformation of lung epithelial cells associated with PM_(2.5)exposure,and discussed the main biological mechanisms,including epigenetics,tumor microenvironment,and other biological pathways.Besides,the potential research directions of malignant transformation of lung epithelial cells associated with PM_(2.5)exposure were proposed.This work aims to provide a scientific basis and reference for public health management and air quality assessment.