氧化还原稳态调控机制与肿瘤治疗

Regulation Mechanisms of Redox Homeostasis and Cancer Therapy

肿瘤往往处于高氧化状态,随着研究的不断深入,人们逐渐发现细胞内氧化还原状态与肿瘤的关系高度复杂,其促瘤和抑瘤效应均有报道。明确氧化还原稳态调控机制,有望为精准靶向该机制,提高肿瘤治疗效果带来新的契机。该文将对氧化还原稳态调控机制及其在肿瘤治疗中应用的最新进展作一综述。

Cancers are often in a high oxidation state.With the deepening of research,it is gradually found that the relationship between intracelluar redox status and cancer is complex,and both of its pro-tumor and anti-tumor effects have been reported.Clarifying the regulation mechanism of redox homeostasis is expected to bring new opportunities for precisely targeting this mechanism and improve the effect of cancer therapy.In this review,the latest progress in the regulation mechanism of redox homeostasis and its application in cancer therapy will be reviewed.