摘要
肥胖会导致包括癌症在内的多种恶性疾病。流行病学研究表明,过度肥胖会增加患乳腺癌的风险,并使患者的预后恶化。肥胖患者脂肪组织功能障碍的特点是白色脂肪细胞的肥大和增生。脂肪间充质干细胞是从白色脂肪组织中分离出来的一种间充质干细胞,具有很强的增殖和分化能力。脂肪间充质干细胞作为乳腺癌潜在的肿瘤启动子,通过激活多种细胞内信号促进肿瘤进展和侵袭。然而,关于脂肪间充质干细胞与乳腺癌细胞相互作用的报道并不一致,其可能的分子机制还有待进一步探讨。该综述将重点总结近年来脂肪间充质干细胞影响乳腺癌进展的相关研究,以期为乳腺癌的治疗提供新的策略。
Obesity can cause a variety of malignant diseases including cancer.Epidemiology shows that excessive obesity will increase the risk of breast cancer and worsen the prognosis.Adipose tissue dysfunction in obese patients is characterized by hypertrophy and hyperplasia of white adipose cells.Adipose-derived mesenchymal stem cells are a kind of mesenchymal stem cells isolated from white adipose tissue,which have strong proliferation and differentiation abilities.As a potential tumor promoter of breast cancer cells,adipose-derived mesenchymal stem cells support tumor progression and invasion by activating multiple intracellular signals.However,there are conflicting reports on the interaction between adipose-derived mesenchymal stem cells and breast cancer cells,and the possible molecular mechanisms remain to be further explored.This review will focus on recent studies on the effects of adipose-mesenchymal stem cells on breast cancer progression,with the aim of providing novel strategies for breast cancer therapy.
作者
董浩楠
柳素玲
DONG Haonan;LIU Suling(Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences,Shanghai Medical College,Key Laboratory of Breast Cancer in Shanghai,Shanghai 200032,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第4期615-626,共12页
Chinese Journal of Cell Biology
基金
国家重点研发计划“干细胞及转化研究”(批准号:2020YFA0112300)
国家自然科学基金(批准号:81930075)资助的课题。
关键词
脂肪间充质干细胞
乳腺癌
肿瘤微环境
adipose-derived mesenchymal stem cells
breast cancer
tumor microenvironment