肿瘤转移过程中的细胞代谢调控

Regulation of Metabolism during Tumor Metastasis

转移是90%癌症患者死亡的主要原因。相比原位肿瘤,转移的肿瘤表现出截然不同的代谢特征。这些代谢上的异常在肿瘤细胞迁移、侵袭、抗失巢凋亡及远端定植过程中发挥重要作用。因此,深入理解肿瘤转移过程中的代谢重编程机制,有助于利用肿瘤细胞的代谢弱点限制肿瘤转移,进而为发生转移的癌症患者提供有效治疗手段。

Metastasis is the primary cause of 90%of cancer-associated death.Compared with primary tumor,metastatic tumor displays distinct metabolic traits.It has been shown that those metabolic dysregulations play a crucial role in migration,invasion,anti-anoikis and metastatic colonization of tumor cells.Thus,better understanding of the mechanism underlying metabolic reprogramming during metastasis helps to identify metabolic vulnerabilities in tumor cells to dampen metastasis,thereby providing the effective therapeutic strategy for metastatic cancer.