基于光学相位共轭的数字化波前整形技术 (特邀)

Wavefront shaping technology based on digital optical phase conjugation(invited)

光在生物组织中传播时,会被微观尺度上不均匀的组织随机散射,这种现象严重制约了光学技术在生物医学中的应用。波前整形技术将散射过程当成一个确定性的过程,通过测量散射效应造成的相位延迟并利用空间光调制器进行逐点补偿,可以实现散射光的操控与重新聚焦。在各类波前整形技术中,基于光学相位共轭的数字化波前整形技术具有可调控自由度高、系统响应速度快等优点,最适宜与生物医学应用相结合,如生物活体成像、操控、治疗等。文中将重点关注基于光学相位共轭的数字化波前整形技术的发展,探讨该技术在应用研发中面临的主要技术瓶颈和挑战,并概述其应用开展情况。

Optical scattering inherent in biological tissue prohibits optical technologies from being widely used in biomedical applications.Wavefront shaping treats optical scattering as a deterministic process,enabling the control of scattered light by point-by-point phase compensation through spatial light modulators.Among various wavefront shaping technologies,digital optical phase conjugation controls the largest number of degrees of freedom and has the fastest speed,which is suitable for biomedical applications such as live-tissue imaging,manipulation,and therapy.This paper will describe the development of digital optical phase conjugation,discuss the main technological challenges encountered,and speculate on future applications.