腔道介入治疗仪对盆腔炎症包块患者细胞因子的影响

Effect of intracavitary interventional therapy instrument on cytokines in patients with pelvic inflammatory mass

目的探讨腔道介入治疗仪对盆腔炎症包块患者细胞因子的影响。方法选取2018年10月至2020年6月河北省沧州市人民医院妇科收治的130例盆腔炎症包块患者为研究对象,按随机数字表法将其分为用药组、治疗仪组,各65例。用药组给予甲硝唑联合多西环素治疗,治疗仪组给予腔道介入治疗仪治疗。观察两组治疗前后细胞因子水平[粒细胞-巨噬细胞集落刺激因子(GM-CSF)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)]、血液流变学、盆腔包块直径、疼痛程度,统计两组临床疗效及不良反应。结果治疗后,两组GM-CSF、CRP、TNF-α、IL-6水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血液流变学指标低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组盆腔包块直径及视觉模拟评分法评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,治疗仪组临床疗效优于用药组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用腔道介入治疗仪治疗盆腔炎症包块患者效果显著,可降低细胞因子,值得临床推广使用。

Objective To investigate the effect of intracavitary interventional therapy instrument on cytokines in patients with pelvic inflammatory mass.Methods A total of 130 patients with pelvic inflammatory mass admitted to the Department of Gynecology,Cangzhou People’s Hospital of Hebei Province from October 2018 to June 2020 were selected as the research objects,according to the random number table method,they were divided into medication group and treatment instrument group,with 65 ceses in each group.The medication group was treated with Metronidazole combined with Doxycycline,while the treatment instrument group was treated with luminal interventional therapy instrument.The levels of cytokines(granulocyte-macrophage colony-stimulating factor[GM-CSF],C-reactive protein[CRP],tumor necrosis factor-α[TNF-α],and interleukin-6[IL-6]),hemorheology,pelvic mass diameter,and pain degree were observed before and after treatment,the clinical efficacy and adverse reactions of the two groups were statistically analyzed.Results After treatment,the levels of GM-CSF,CRP,TNF-α,and IL-6 in the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the hemorheological indexes of the two groups were lower than those before treatment,and the hemorheological indexes of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the pelvic mass diameter and visual analogue scales score of the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the clinical effect of the therapeutic apparatus group was better than that of the drug group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The treatment of patients with pelvic inflammatory mass by cavity interventional therapy device is effective and can reduce cytokines,which is worthy of clinical promotion.