联合Septin9基因甲基化、FOBT及CEA检测在结肠癌患者诊断中的临床意义

目的 探讨联合Septin9基因甲基化、FOBT及CEA对结肠癌诊断的临床意义.方法 回顾性分析2016年1月至2020年9月本院收治的结肠癌患者及其健康对照组临床资料,分为结肠癌组56例、癌前病变组56例和健康对照组21例.通过统计三组Septin9基因甲基化、FOBT及CEA数据,绘制工作特征曲线(ROC)并比较ROC曲线下面积(AUC).结果 Septin9基因甲基化在结肠癌患者中阳性率最高;ROC曲线结果显示联合FOBT、CEA以及Septin9甲基化的AUC为0.9127(95%CI).3项评价指标联合检测在结肠癌患者诊断效能最高,差异具有统计学意义(P<0.05).结论 联合检测结肠癌患者外周血血浆游离Septin9基因甲基化、FOBT及CEA能够显著提高结肠癌患者的诊断效能.

Objective To investigate the clinical significance of Septin9 gene methylation,FOBT and CEA in the diagnosis of colon cancer.Methods Clinical data of colon cancer patients admited to our hospital from January 2016 to September 2020 and their control group were retrospectively analyzed,which were divided into colon cancer group,precancerous lesion group and healthy control group,including 56 cases,56 cases and 21 cases,respectively.The Septin9 gene methylation,FOBT and CEA data of patients in the three groups were statistically analyzed to draw operating characteristic curve(ROC)and compare the area under ROC curve(AUC).Results Septin9 gene methylation had the highest positive rate in colon cancer patients.ROC curve resuls showed that the AUC of methylation of FOBT,CEA and Septin9 was 0.9127(95%CI).The combined detection of the three evaluation indexes had the highest diagnostic eficacy in colon cancer patients,and the dfference was statistically significant(P<0.05).ConclusionCombined detection of Septin9 gene methylation,FOBT and CEA in peripheral blood plasma can significantly improve the diagnostic ficiency of colon cancer patients.