健康体检女性HPV感染和细胞学结果分析

目的 探讨健康体检人群的人类乳头瘤病毒(HPV)分布情况,以更好地为该地区宫颈癌(UCC)防治提供科学依据.方法 选取2013年8月至2019年4月在浙江医院体检的健康女性的宫颈上皮细胞样本,进行HPV基因分型和液基薄层细胞检测(TCT)检查结果进行回顾性研究.结果 共调查了10,248例健康女性的HPV和TCT检查结果,发现HPV的感染率为10.68%.高风险HPV感染率为7.88%,低风险HPV感染率为2.15%.最常见的6个亚型为HR16、HR52、HR58、HR53、HR39和HR18.95.9%的研究对象TCT检查未见上皮内病变与肿瘤细胞.在TCT检查为不典型鳞状细胞(ASCUS)的研究对象中,HPV感染率为100%.其中,高危型占比95.23%.不同年龄组人乳头状瘤病毒亚型分布不同.21~30岁HPV感染率最高为14.20%.TCT结果为ASCUS的研究对象中,41~50岁占比最高(0.55%).结论 健康体检人群HPV感染情况与国内HPV感染相似,有性生活后各个年龄段的女性均有必要进行HPV分型检测和TCT检查.

Objective To investigate the HPV distribution in healthy populations in various districts in Hangzhou through physical checkups to provide a scientific basis for cervical cancer prevention and treatment in the region.Methods In this work,a retrospective study was conducted to alyze the resuls of HPV genotyping and the thn-pre cytological test(TCT)of cevica epthelal cels cllecte from healhy women during physical examinations t the Zhejang Hospital from August 2013 to April 2019.Results A total of 10,248 healthy women were investigated for HPV and TCT.Of these women,10.68% had an HPV infection,7.88% had a highrisk HPV infection,and 2.15% had a low-risk HPV infection.The six most common HPV subtypes were HR 16,HR52,HR58,HR53,HR39 and HR18.The TCT results of 95.9% of the tested subijects showed no intraepithelal lsions or tumor cell.100%individuaks with severity greater than or equal to atypical squamous cels of undetermined signifcance(ASCUS)in the TCT had HPV infections,and 95.23% of these subjects had high-risk HPV infections.Al subjects were divided intofive age groups (21~30,31~40,41~50,51~60 and>60 years old),which had varying levels of HPV distribution.The highest HPV infection rate(14.20%)was identified for the 21-30-year-old age group.Individuals of 51~60 years of age had the highest likelihood(0.55%)of severity greater than or equal to ASCUS in the TCT.ConclusionWomen of allages who are sexully active should take HPV genotyping and TCT.