摘要
Environmental threats often trigger innate defensive responses in mammals.However,the gradual development of functional properties of these responses during the postnatal development stage remains unclear.Here,we report that looming stimulation in mice evoked fight behavior commencing at P14-16 and had fully developed by P20-24.The visual-evoked innate defensive response was not significantly altered by sensory deprivation at an early postnatal stage.Furthermore,the percentages of wide-field and horizontal cells in the superior colliculus were notably elevated at P20-24.Our findings define a developmental time window for the formation of the visual innate defense response during the early postnatal period and_provide important insight into the underlying mechanism.
基金
This work was supported by the National Natural Science Foundation of China(31930047,91732304 and 31630031)
The Strategic Priority Research Program of the Chinese Academy of Science(XDB32030100)
Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017)
the Natural,Science Foundationo Gfuangdong,Province(2018A030313439)
a Shenzhen Government grant(JCYJ20170413164535041)
Shenzhen Key Science and Technology Infrastructure Planning Project(ZDKJ20190204002)
Key Laboratory of CAS(2019DP173024)
The Ten Thousand Talents Program
The Guangdong Special Support Program
Chang Jiang Scholars Program
Intermational PartnershipProgram of theChinese Academy of Sciences(172644KYS820170004)
and the Key-Area Research and Development Program of Guangdong Province(2018B030331001).
