新型吡唑酰胺类农药吡噻菌胺的研究进展

A Review on Penthiopyrad:A Novel Pyrazole Amide Pesticide

为阐明新型吡唑酰胺类杀菌剂吡噻菌胺的生态暴露风险与环境行为归趋,本文从合成路径、生物活性、生态毒理、分析方法和环境行为五方面进行分析总结,并对其应用前景进行展望。指出吡噻菌胺对真菌孢子萌发抑制作用显著,防治效果优于治疗效果;吡噻菌胺对水生生物具有较高的生态毒性,且对细胞活力及氧化应激具有显著的对映体选择性差异。建议后续深入开展不同环境下吡噻菌胺的行为特征及其水生生态毒理学研究,特别是对映体选择性的分子机制,探索高效低风险的手性对映体,建立科学精准的风险评估体系,降低其对水生生物安全和人类生殖健康的高潜在暴露风险。

To elaborate the ecological exposure risk and environmental fate of a novel pyrazole amide fungicide penthiopyrad, the authors summarized the synthesis path, biological activity, ecological toxicology, analytical methodology and environmental fate of penthiopyrad, as well as its application prospects. Penthiopyrad exhibited a significant inhibitory effect on fungal spore germination, and the prevention effect was better than the treatment effect. High ecotoxicity of penthiopyrad was observed to aquatic organisms, whereas obvious enantioselective differences were demonstrated to cell viability and oxidative stress. Further studies were recommended to investigate the fate characteristic and aquatic ecotoxicology of penthiopyrad under various circumstances, especially focus on the molecular mechanism of enantioselectivity. The chiral enantiomer of penthiopyrad with high-activity and low-risk was also explored to develop a scientific and accurate risk assessment system, and to reduce the high potential exposure risks to aquatic biological safety and human reproductive health.