MNNG溶液联合多因素诱导胃癌前病变大鼠模型研究进展

Research progress of MNNG solution combined with multi-factor induction of gastric precancerous lesion in rats

胃癌前病变是慢性萎缩性胃炎发展成胃癌的关键环节,积极有效地开展胃癌前病变的干预对胃癌防治有重大意义。目前MNNG溶液(N-methyl-N’-nitro-N-nitrosoguanidine,MNNG)联合多因素造模法是胃癌前病变动物研究中常用的方法,但对于MNNG溶液的给药方式、浓度及其联合因素的具体选择、用药时间还尚未明确,本文结合近五年的PLGC大鼠造模情况,总结出四种使用率较高的MNNG溶液复合法,在其浓度、给药方式及多因素联合作用的背景下讨论胃癌前病变大鼠的造模研究进展,以期为动物实验的开展与进一步深入研究PLGC提供模型方法上的参考。

Precancerous lesions of gastric cancer(PLGC)are a key link between chronic atrophic gastritis and gastric cancer,and pre-gastric cancer intervention is significant for impacting gastric cancer.MNNG solution,in combination with a multi-factor modeling method,is a common method applied to the study of PLGC.However,at present,the prospects of MNNG solution use are still unclear,as the concentration and its factors are specific.This manuscript presents nearly five years’worth of data from PLGC production in rats,summarizes four MNNG solution composite method with high usage rates,and discusses the model research progress in pre-stomach cancer rats in the context of MNNG solution concentration,administration,and multi-factor combination to guide the development of model method,animal experiments and further research on PLGC.