中药对排卵障碍性不孕症黄体功能干预的临床效果观察

Clinical Effect of Traditional Chinese Medicine Intervention on Luteal Function in Infertility with Ovulation Disorder

目的探讨中药治疗排卵障碍性不孕症患者的临床效果。方法纳入平顶山市计划生育科学技术研究所2020年2月至2021年12月收治的62例排卵小不孕症患者,回顾性分析研究对象临床资料,根据治疗方式的不同分为对照组和试验组,各31例。对照组单纯给予常规西药治疗,试验组在西药治疗基础上继续给予中药方剂排卵汤治疗,两组均持续治疗3个月,比较治疗前后中医症候积分、卵巢功能和黄体功能的差异,评价两组治疗的有效性和安全性。结果两组治疗前中医证候积分比较差异无统计学意义(P>0.05);治疗后,两组中医证候积分均低于本组治疗前,差异有统计学意义(P<0.05);且试验组治疗后中医证候积分低于对照组,差异有统计学意义(P<0.05)。两组治疗前卵巢功能各项指标比较差异无统计学意义(P>0.05);治疗后,两组卵巢功能指标均低于本组治疗前,差异有统计学意义(P<0.05),且试验组治疗后卵巢功能指标水平低于对照组,差异有统计学意义(P<0.05)。两组治疗前黄体功能各项指标比较差异无统计学意义(P>0.05);治疗后,两组睾酮、黄体生成素和卵泡刺激素水平低于本组治疗前,雌二醇水平高于本组治疗前,差异有统计学意义(P<0.05),且试验组治疗后睾酮、黄体生成素和卵泡刺激素水平低于对照组,雌二醇水平高于对照组,差异有统计学意义(P<0.05)。试验组治疗有效率(93.55%)高于对照组(74.19%),差异有统计学意义(P<0.05)。试验组不良反应发生率(12.90%)低于对照组(38.71%),差异有统计学意义(P<0.05)。结论中药治疗排卵障碍性不孕症患者具有较高的安全性和有效性,改善患者的临床症状的同时调节机体的卵巢功能和黄体功能,临床治疗优势显著。

Objective To explore the clinical effect of traditional Chinese medicine in the treatment of infertility patients with ovulation disorder.Methods A total of 62 patients with small ovulatory infertility admitted to Pingdingshan Institute of Family Planning Science and Technology from February 2020 to December 2021 were enrolled.The clinical data of the subjects were retrospectively analyzed and divided into control group and experimental group according to different treatment methods,with 31 cases in each group.The control group was treated with conventional western medicine,while the experimental group was treated with ovulation decoction on the basis of western medicine.The two groups were treated for 3 months.The differences of TCM syndrome score,ovarian function and luteal function before and after treatment were compared,and the efficacy and safety of the two groups were evaluated.Results There was no significant difference in TCM syndrome scores between the two groups before treatment(P>0.05).After treatment,the TCM syndrome scores of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome score of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in ovarian function indexes between the two groups before treatment(P>0.05).After treatment,the ovarian function indexes of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05),and the ovarian function indexes of the experimental group were lower than those of the control group after treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the indexes of luteal function between the two groups before treatment(P>0.05).After treatment,two groups of testosterone,luteinizing hormone and follicle-stimulating hormone levels lower than before treatment,estradiol levels higher than the group before the treatment,the difference was statistically significant(P<0.05),and the experimental group after treatment,luteinizing hormone and follicle-stimulating hormone testosterone levels lower than the control group,the estradiol levels higher than the control group,the difference was statistically significant(P<0.05).The effective rate of the experimental group(93.55%)was higher than that of the control group(74.19%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in experimental group(12.90%)was lower than that in control group(38.71%),and the difference was statistically significant(P<0.05).Conclusion Traditional Chinese medicine has high safety and effectiveness in the treatment of infertility patients with ovulation disorder.It can improve the clinical symptoms of patients and regulate the ovarian function and luteal function of the body at the same time.