子痫前期孕妇血清铁蛋白、胱抑素C水平与妊娠结局的相关性分析

Correlation Analysis of Serum Ferritin and Cystatin C Levels with Pregnancy Outcome in Preeclampsia

目的探究子痫前期孕妇血清铁蛋白(SF)、胱抑素C(CysC)水平与妊娠结局的相关性。方法选取2019年4月至2021年1月睢县妇幼保健院75例子痫前期孕妇的数据资料进行回顾性分析,将75名患者设为观察组,观察组内根据病情程度划分为轻度组41例和重度组34例,选取同期的70名健康孕妇作为对照组,根据观察组孕妇是否出现不良妊娠结局做进一步分组,分为结局良好组和结局不良组,对比重度组,轻度组,对照组的血清SF、CysC水平。分析观察组孕妇出现不良妊娠结局的情况。子痫前期孕妇出现不良妊娠结局的单因素、多因素分析结果。结果重度组,轻度组,对照组的血清SF、CysC水平对比,差异有统计学意义(P<0.05)。观察组患者中共出现不良妊娠结局的个体33例,妊娠结局良好的个体42例。多因素分析结果显示,子痫前期孕妇的血清SF水平、血清CysC水平均成为是否出现不良妊娠结局的独立影响因素,差异均有统计学意义(P<0.05)。利用血清SF水平、血清CysC水平、logistic预测概率对于子痫前期孕妇是否会出现不良妊娠结局进行推断,约登指数分别为59.74%、61.90%、72.94%。结论子痫前期孕妇的血清SF、CysC水平能够反映出病情程度,且与妊娠结局密切相关,可作为评估不良妊娠结局的依据。

Objective To explore the correlation between serum ferritin(SF),Cystatin C(CysC)levels and pregnancy outcomes in pregnant women with preeclampsia.Methods A total of 75 pregnant women with preeclampsia who visited Sui County Maternal and Child Health Hospital from April 2019 to January 2021 were retrospectively analyzed.Setting all of the patients as observation group,and according to the degree of disease was divided into mild group(41 cases)and severe group(34 cases),and selecting 70 healthy pregnant women in the same period as control group.According to the observation group whether pregnant women do further grouped in adverse pregnancy outcomes,divided into ending the good group and negative group.The serum SF and CysC levels of the severe group,the mild group and the control group were compared.The adverse pregnancy outcome was analyzed in the observation group.Univariate and multivariate analysis of adverse pregnancy outcomes in preeclampsia.Results There were statistically significant differences in serum SF and CysC levels among severe group,mild group and control group(P<0.05).In the observation group,there were 33 individuals with adverse pregnancy outcomes and 42 individuals with good pregnancy outcomes.The results of multivariate analysis showed that the serum SF level and serum CysC level of preeclampsia pregnant women were independent influencing factors for adverse pregnancy outcomes,and the differences were statistically significant(P<0.05).The Youden index was 59.74%,61.90%and 72.94%,respectively,when the serum SF level,serum CysC level and logistic prediction probability were used to infer whether preeclampsia women would have adverse pregnancy outcomes.Conclusion Serum SF and CysC levels in preeclampsia women can reflect the severity of the disease and are closely related to pregnancy outcomes,which can be used as a basis for evaluating adverse pregnancy outcomes.