SAA、PCT及淋巴细胞计数在脓毒血症预后评估中的作用分析

The role of SAA,PCT and lymphocyte count in the prognosis assessment of sepsis

目的探讨血清淀粉样蛋白A(SAA)、降钙素原(PCT)及外周血淋巴细胞计数在脓毒血症预后评估中的作用。方法选取2019年11月至2021年11月遂宁市中心医院ICU收治的118例脓毒血症患者为研究组,根据患者预后情况分为死亡组和存活组,选取同时间段92名行健康体检者为对照组。比较各组SAA、PCT水平及淋巴细胞计数,分析SAA、PCT联合淋巴细胞计数对脓毒血症预后的预测价值。结果研究组SAA、PCT水平较对照组高、淋巴细胞计数较对照组少,差异均有统计学意义(P<0.05)。研究组所有患者均成功完成随访,随访期间共37例患者死亡,81例患者存活。死亡组SAA、PCT水平较生存组高、淋巴细胞计数较生存组少,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,SAA、PCT、淋巴细胞计数三者联合检测对脓毒血症患者预后预测价值的AUC为0.873[95%CI(0.795~0.950)](P<0.05)。结论SAA、PCT及外周血淋巴细胞计数在脓毒血症患者中存在异常表达,可能与脓毒血症患者预后密切相关,通过联合检测上述因子水平有助于评估患者预后情况。

Objective To investigate the effects of serum amyloid A Protien(SAA)and Procalcitonin(PCT)and peripheral blood lymphocyte count in the prognosis assessment of sepsis.Methods 118 sepsis patients admitted to ICU of Suining Central Hospital from November 2019 to November 2021 were selected as the study group and were divided into the death group and the survival group according to the prognosis,and 92 cases of health examination during the same period were selected as the control group.SAA,PCT levels and lymphocyte count were compared between the groups,the prognostic value of SAA and PCT combined with lymphocyte count in sepsis patients was analyzed.Results The levels of SAA and PCT in the study group were higher than those in the control group,and the lymphocyte count was lower than that in the control group,and the differences were all statistically significant(P<0.05).All patients were successfully followed up,during which 37 patients died and 81 patients survived.The levels of SAA and PCT in the death group were higher than those in the survival group,and the lymphocyte count was lower than that in the survival group,the differences were all statistically significant(P<0.05).The ROC curve analysis results showed that the AUC of SAA,PCT and lymphocyte count combined detection for prognosis prediction of sepsis patients was 0.873[95%CI(0.795~0.950)].Conclusion SAA,PCT and peripheral blood lymphocyte count were abnormally expressed in sepsis patients,which may be closely related to the prognosis of sepsis patients.The combined detection of these factors can help to evaluate the prognosis of patients.