胃近端癌与远端癌中CEA与Ki-67的表达及临床意义

Expression and clinical significance of CEA and Ki-67 in proximal and distal gastric carcinomas

目的:探讨癌胚抗原(CEA)和Ki-67在胃近端癌组织与远端癌组织中的表达及临床意义。方法:收集某院手术成功的连续的进展期胃癌病例,近端胃癌72例,远端胃癌35例。采用免疫组织化学方法分别检测近端和远端胃癌组织中CEA和Ki-67的表达水平,并结合相关的临床病理资料,分析CEA和Ki-67在近、远端胃癌的表达差异。结果:CEA在近端和远端胃癌中的阳性表达率分别为90.3%和94.3%,差异无统计学意义(P>0.05);Ki-67在近端胃癌和远端胃癌中的高表达率分别为83.3%和85.7%,差异无统计学意义(P>0.05);CEA在近端胃癌的阳性表达率及Ki-67在近端胃癌的高表达率与胃癌患者性别、年龄、肿瘤大小、淋巴结是否转移及病理分期无关,差异无统计学意义(P>0.05);CEA在远端胃癌的阳性表达率及Ki-67在远端胃癌的高表达率与胃癌患者性别、年龄、肿瘤大小、淋巴结是否转移及病理分期无关,差异无统计学意义(P>0.05)。结论:近端胃癌和远端胃癌存在不同的临床病理生理特点和预后,CEA和Ki-67在2者中的表达差异无统计学意义,呼吁更多的研究从基因表达层面进一步探索调控两者表达的基因学差异性。

Objective:To investigate the expression and clinical significance of carcinoembryonic antigen(CEA)and Ki-67 in proximal and distal gastric cancer.Methods:A total of consecutive 72 cases of proximal gastric cancer and 35 cases of distal gastric cancer were collected who underwent successful operations in a hospital.The expression levels of CEA and Ki-67 in proximal and distal gastric cancer tissues were detected by immunohistochemical method,and,combined with relevant clinicopathological data,the expression differences of CEA and Ki-67 in proximal and distal gastric cancer were analyzed.Results:The positive expression rates of CEA in proximal and distal gastric cancer were 90.3%and 94.3%,respectively,with no significant difference between them(P>0.05).The high expression rates of Ki-67 in proximal gastric cancer and distal gastric cancer were 83.3%and 85.7%,respectively,there being no significant difference(P>0.05).The positive rate of CEA in proximal gastric cancer and the high expression rate of Ki-67 in proximal gastric cancer had no significant correlation with gender,age,tumor size,lymph node metastasis and pathological stage(P>0.05).The positive rate of CEA expression in distal gastric cancer and the high expression rate of Ki-67 in distal gastric cancer had no significant correlation with gender,age,tumor size,lymph node metastasis and pathological stage(P>0.05).Conclusion:There are different clinicopathological characteristics and prognoses between proximal gastric cancer and distal gastric cancer,but this study found that there is no difference in the expression of CEA and Ki-67 between them.It is essential to broaden our thinking and to search for other genes for further research so as to explore the differences in gene expressions between proximal and distal gastric cancer.