基于痰瘀互结理论探讨血脂异常对轻度认知障碍影响

Effect Exploration of Dyslipidemia on Mild Cognitive Impairment Based on the Theory of Phlegm and Blood Stasis

轻度认知障碍(mild cognitive impairment,MCI)是指存在客观和主观的认知或记忆损害,但日常生活能力正常的状态,是正常衰老和轻度痴呆[尤其是阿尔茨海默病(Alzheimer’s disease,AD)]之间的过渡阶段,是老年痴呆发生的危险因素,同时也是治疗老年痴呆的最佳时间。痰瘀与血脂异常分属于中医与西医概念,均与轻度认知障碍密切相关,该文通过探讨痰瘀互结和血脂异常相关生物学标志与轻度认知障碍的相关性,旨在丰富痰瘀互结致呆的中医理论及探讨血脂异常引起MCI的生物学机制。

Mild cognitive impairment(MCI)refers to a condition of normal daily life that involves subjective or objective impairment of memory or cognition.MCI is a transitional stage between normal aging and mild dementia(especially Alzheimer’s disease).It is a risk factor for the development of Alzheimer’s disease and also the optimal window of time for its treatment.Phlegm and blood stasis and dyslipidemia belong to the concepts of traditional Chinese medicine and Western medicine,both of which are closely related to mild cognitive impairment.Through literature review,this paper discusses the correlation between biological indicators related to phlegm and blood stasis and dyslipidemia and mild cognitive impairment.