妇科肿瘤卡铂化疗所致过敏反应的中国专家共识(2022年版)

China expert consensus on hypersensitivity reactions induced by carboplatin chemotherapy of gynecologic tumors in China(2022 Edition)

铂类药物广泛应用于妇科恶性肿瘤的化疗。卡铂作为顺铂的衍生物,属于第二代铂类抗癌药,具有“等效、低毒”的特点。过敏反应是卡铂化疗过程中的常见并发症,严重急性过敏反应可危及患者生命。预防卡铂过敏、及时诊断并给予规范治疗,对于提高妇科肿瘤治疗效果、降低患者死亡风险具有重要意义。本共识的制定,旨在为妇科肿瘤医师提供借鉴和指引。

Platinum drugs are currently widely used in the chemotherapy of gynecological tumors.As a derivative of cisplatin,carboplatin is a second-generation platinum-based anticancer drug with the characteristics of "equipotency" and "low toxicity".Hypersensitivity reactions to carboplatin are common complications during its treatment,but acute severe hypersensitivity reactions can endanger the lives of patients.Therefore,prevention of carboplatin-induced hypersensitivity,timely diagnosis of hypersensitivity reactions and proper treatments are important to improve the overall efficacy of carboplatin antitumor therapy and to reduce the risk of mortality.Hence,here comes the consensus on hypersensitivity reactions induced by carboplatin chemotherapy of gynecologic tumors in China(2022 edition),aiming to provide guidelines for clinical practitioners and to standardize treatment behaviors.