芪苈强心胶囊治疗老年人急性心肌梗死合并心力衰竭的效果分析

Effect Analysis of Qili Qiangxin Capsule in the Treatment of Elderly Patients with Acute Myocardial Infarction Complicated with Heart Failure

目的:探讨重组人脑利钠肽联合芪苈强心胶囊治疗老年人急性心肌梗死合并心力衰竭的效果。方法:选取重庆市第七人民医院2019年1月至2021年1月期间收治的90例急性心肌梗死合并心力衰竭患者,随机分为对照组与观察组,各45例。对照组患者实施重组人脑利钠肽治疗,观察组患者实施重组人脑利钠肽联合芪苈强心胶囊治疗。比较两组患者心肌功能、血清生化指标及6 min步行距离。结果:治疗后两组患者的左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)均有不同程度下降,左心室射血分数(LVEF)有不同程度升高,且治疗后观察组患者的LVEDV、LVESV均低于对照组,LVEF高于对照组,差异具有统计学意义(P<0.05);治疗后两组患者的心肌肌钙蛋白I(cTnI)、N末端脑钠肽前体(NT–proBNP)、肌酸激酶同工酶(CK–MB)均有不同程度下降,且治疗后观察组患者的cTnI、NT–proBNP、CK–MB均低于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者6 min步行距离均有所提升,且治疗后观察组患者6 min步行距离长于对照组,差异具有统计学意义(P<0.05)。结论:对老年急性心肌梗死合并心力衰竭患者积极实施重组人脑利钠肽联合芪苈强心胶囊治疗,能有效改善患者心肌功能、提高患者心输出量及改善运动耐力,进而减少心脏损伤,缓解患者心力衰竭程度。

Objective To investigate the effect of recombinant human brain natriuretic peptide combined with Qili Qiangxin capsule on elderly patients with acute myocardial infarction complicated with heart failure.Methods A total of 90 patients with acute myocardial infarction complicated with heart failure admitted to the Seventh People’s Hospital of Chongqing from January 2019 to January 2021 were selected and randomly divided into a control group and an observation group,with 45 cases in each group.Patients in the control group were treated with recombinant human brain natriuretic peptide,while patients in the observation group were treated with recombinant human brain natriuretic peptide combined with Qili Qiangxin capsule.Myocardial function,serum biochemical parameters and 6-min walking distance were compared between the two groups.Results After treatment,the left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) of the two groups decreased to varying degrees,and the left ventricular ejection fraction (LVEF) increased to varying degrees.After treatment,the LVEDV and LVESV of the observation group were lower than those of the control group,and the LVEF was higher than that of the control group,the differences were statistically significant (P < 0.05).After treatment,the levels of cardiac troponin I (cTnI),N-terminal pro-brain natriuretic peptide (NT-proBNP),creatine kinase isoenzyme (CK-MB) in the two groups were decreased to different degrees,and the levels of cTnI,NT-proBNP,CK-MB in the observation group were lower than those in the control group,and the differences were statistically significant (P < 0.05).After treatment,the 6 min walking distance of patients in the two groups was improved,and the 6 min walking distance of patients in the observation group was longer than that in the control group,and the difference was statistically significant (P < 0.05).Conclusion Active implementation of recombinant human brain natriuretic peptide combined with Qili Qiangxin capsule in the treatment of elderly patients with acute myocardial infarction complicated with heart failure.It can effectively improve myocardial function,cardiac output and exercise endurance,and reduce cardiac injury and alleviate the degree of heart failure.