摘要
Mechanochemical coupling cycles underlie the work-generation mechanisms of biological systems and are realized by highly regulated conformational changes of the protein machineries.However,it has been challenging to utilize protein conformational changes to do mechanical work at the macroscopic level in biomaterials,and it remains elusive to con-struct macroscopic mechanochemical devices based on molecular-level mechanochemical coupling sys-tems.Here,the authors demonstrate that protein folding can be utilized to realize protein’s mechano-chemical cycles at both single-molecule and macro-scopic levels.
