摘要
Short DNA represents an important class of bioma-cromolecules that arewidely applied in gene therapy,editing,and modulation.However,the development of simple and reliable methods for their intracellular delivery remains a challenge.Herein,we describe that seven water-soluble,homogeneous supramole-cular organic frameworks(SOFs)with a well-defined pore size and high stability in water that can accom-plish in situ inclusion of single-stranded(ss)and double-stranded(ds)DNA(21,23,and 58 nt)and effective intracellular delivery(including two non-cancerous and six cancerous cell lines).
基金
We thank the National Natural Science Foundation of China(Nos.21432004 and 21529201)for financial sup-port,Shanghai Synchrotron Radiation Facility for provid-ing BL16B1 and BL14B1 beamlines for collecting the synchrotron X-ray-scattering and diffraction data,and the SIBYLS Beamline 12.3.1 of the Advanced Light Source(ALS),Lawrence Berkeley National Laboratory,for collecting solution-phase,synchrotron small-angle X-ray-scattering data.
