基于表面增强拉曼光谱标记技术的生物传感器用于农药残留检测的研究进展

Recent Advances in Biosensors Based on Surface Enhanced Raman Scattering Labels for the Detection of Pesticide Residues

近年来,表面增强拉曼光谱(surface enhancement Raman spectroscopy,SERS)标记技术因具有高灵敏度、可多路复用、强抗光漂白性和较好的分子指纹保真度等特性而备受瞩目,并已成功应用于传感分析及生物成像领域。本综述主要总结了基于SERS标记技术的生物传感器的原理及其在农药残留快速检测领域中的最新研究进展,重点介绍了SERS标签的设计与制备及基于不同识别元件传感系统的研究现状。同时,对其面临的挑战和解决方案进行了探讨,以期促进SERS标记技术在农药残留检测及食品安全检测方面的应用。

Recently,surface enhanced Raman scattering(SERS)labels have attracted researchers’attention owing to their high sensitivity,excellent multiplexing ability,insensitivity to photobleaching and good fidelity of molecular fingerprint,and have been successfully applied to sensing analysis and biological imaging.In this review,we summarize the principle of SERS label-based biosensors,and the state of the art in their application for rapid detection of pesticide residues.The focus of this review is on the design and fabrication of SERS labels and the current status of sensing systems based on different recognition elements.Meanwhile,the challenges in this field are discussed and possible solutions to them are proposed.This review is expect to help expand the application of SERS labels in the detection of pesticide residues and food safety.